Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities
Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of...
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| Format: | Article |
| Language: | English English |
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Elsevier
2016
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| Online Access: | http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf |
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| author | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden |
| author_facet | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden |
| author_sort | Aminudin, Nurul Iman |
| building | IIUM Repository |
| collection | Online Access |
| description | Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5-
hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene,
amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and a-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71mg/mL and showed inhibition towards a-glucosidase enzymatic activity with IC50 93.25mM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. |
| first_indexed | 2025-11-14T16:26:26Z |
| format | Article |
| id | iium-50956 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:26:26Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-509562017-10-04T01:35:43Z http://irep.iium.edu.my/50956/ Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden RS Pharmacy and materia medica Four new 4-substituted coumarins, incrassamarin A (1), B (2), C (3) and D (4) with (7S,8S)-7,8-dihydro-5- hydroxy-7,8-dimethyl-4-propyl-2H,6H-benzo[1,2-b;5,4-b’]dipyran-2,6-dione (5), friedelin, carpachromene, amentoflavone, epiafzelechin and L-quercitrin were isolated from the barks and leaves of Calophyllum incrassatum (Guttiferae). The compounds were isolated and purified by size-exclusion recycling HPLC and column chromatographic techniques. The structures of the compounds were determined by spectroscopic means. The compounds were tested for their cytotoxic activity towards MCF-7 and A-549 cell lines and a-glucosidase enzymatic inhibitory activity. Compound (1) displayed cytotoxic activity against A-549 cell lines with IC50 87.71mg/mL and showed inhibition towards a-glucosidase enzymatic activity with IC50 93.25mM. This is the first report on the isolation of phytochemicals from the barks and leaves of C. incrassatum and their bioactivities. Elsevier 2016-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf application/pdf en http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Razauden (2016) Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities. Phytochemistry Letters, 16. pp. 287-293. ISSN 1874-3900 http://www.sciencedirect.com/science/article/pii/S1874390016300714 10.1016/j.phytol.2016.05.008 |
| spellingShingle | RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Razauden Incrassamarin A–D: Four new 4-substituted coumarins from Calophyllum incrassatum and their biological activities |
| title | Incrassamarin A–D: Four new 4-substituted coumarins from
Calophyllum incrassatum and their biological activities |
| title_full | Incrassamarin A–D: Four new 4-substituted coumarins from
Calophyllum incrassatum and their biological activities |
| title_fullStr | Incrassamarin A–D: Four new 4-substituted coumarins from
Calophyllum incrassatum and their biological activities |
| title_full_unstemmed | Incrassamarin A–D: Four new 4-substituted coumarins from
Calophyllum incrassatum and their biological activities |
| title_short | Incrassamarin A–D: Four new 4-substituted coumarins from
Calophyllum incrassatum and their biological activities |
| title_sort | incrassamarin a–d: four new 4-substituted coumarins from
calophyllum incrassatum and their biological activities |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/ http://irep.iium.edu.my/50956/2/Incrassamarin_A%E2%80%93D_Four_new_4-substituted_coumarins__from.pdf http://irep.iium.edu.my/50956/7/50956_Incrassamarin%20A%E2%80%93D_WoS.pdf |