Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study
The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group N...
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The Spanish Society of Anatomy
2016
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| Online Access: | http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf |
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| author | Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah |
| author_facet | Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah |
| author_sort | Al-Jaufi, Fakhria |
| building | IIUM Repository |
| collection | Online Access |
| description | The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure. |
| first_indexed | 2025-11-14T16:25:30Z |
| format | Article |
| id | iium-50698 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:25:30Z |
| publishDate | 2016 |
| publisher | The Spanish Society of Anatomy |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-506982017-04-04T02:16:56Z http://irep.iium.edu.my/50698/ Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah R Medicine (General) RM Therapeutics. Pharmacology The objective of this study was to examine the effect of Eurycoma longifolia (EL) extract on intima media thickness (IMT) of aorta in Sprague Dawley (SD) rats fed with high-fat diet. Twenty healthy male SD rats were divided into 4 groups of 5 animals each and treated for 12 weeks as follows: Group ND was given only normal diet, Group NDEL was given normal diet and EL, Group HFD was given only high fat diet, Group HFDEL was given HFD and EL extracts. The aortic thicknesses of the intima media were photographed and measured with Dino-Capture® 2.0.In this study, the HFD produced obvious atherosclerotic plaque; treatment with aqueous extract of EL has reduced the size and formation of atherosclerotic plaque. The aortic IMT was more significantly increased in the HFD group than that of ND (p < 0.05); on the other hand, the aortic IMT was more significantly reduced in HFDEL group than that of HFD group (p < 0.05). It is concluded that the aqueous extract of EL significantly attenuated the formation of atherosclerotic plaques in the aorta of rats and preserved the vascular structure. The Spanish Society of Anatomy 2016-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50698/1/Article_2016.pdf application/pdf en http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf Al-Jaufi, Fakhria and Al-Ani, Imad M and Saxena, Anil Kumar and Talib, Norlelawati A. and H. Mokhtar, Rafidah and Ku-Zaifah, Norsidah (2016) Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study. European Journal of Anatomy, 20 (2). pp. 131-136. ISSN 1136-4890 E-ISSN 2340-311X http://eurjanat.com/data/pdf/eja.150350ia.pdf |
| spellingShingle | R Medicine (General) RM Therapeutics. Pharmacology Al-Jaufi, Fakhria Al-Ani, Imad M Saxena, Anil Kumar Talib, Norlelawati A. H. Mokhtar, Rafidah Ku-Zaifah, Norsidah Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title | Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_full | Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_fullStr | Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_full_unstemmed | Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_short | Assessment of anti-atherosclerotic effect of Eurycoma longifolia extract on high-fat diet model in rats. I: Histological study |
| title_sort | assessment of anti-atherosclerotic effect of eurycoma longifolia extract on high-fat diet model in rats. i: histological study |
| topic | R Medicine (General) RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/ http://irep.iium.edu.my/50698/1/Article_2016.pdf http://irep.iium.edu.my/50698/4/50698_Assessment%20of%20anti-atherosclerotic%20effect_Scopus.pdf |