Cholesterol lowering in intermediate-risk persons without cardiovascular disease
Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear wheth...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Massachusetts Medical Society
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/50353/ http://irep.iium.edu.my/50353/7/Cholesterol_Lowering_in_Intermediate-Risk.pdf http://irep.iium.edu.my/50353/11/DR_AZNAN.pdf |
| _version_ | 1848783625123790848 |
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| author | Yusuf, Salim Bosch, Jackie Dagenais, Gilles Jun, Zhu Xavier, Denis Lisheng, Liu Md Aris, Mohd Aznan Mohd Shah, Azarisman Shah ., et. al |
| author_facet | Yusuf, Salim Bosch, Jackie Dagenais, Gilles Jun, Zhu Xavier, Denis Lisheng, Liu Md Aris, Mohd Aznan Mohd Shah, Azarisman Shah ., et. al |
| author_sort | Yusuf, Salim |
| building | IIUM Repository |
| collection | Online Access |
| description | Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear whether the benefits of statins can be extended to an intermediate-risk, ethnically diverse population without cardiovascular disease.
In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants in 21 countries who did not have cardiovascular disease and were at intermediate risk to receive rosuvastatin at a dose of 10 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal
myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included revascularization, heart failure, and resuscitated cardiac arrest. The median follow-up was 5.6 years. |
| first_indexed | 2025-11-14T16:24:19Z |
| format | Article |
| id | iium-50353 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:24:19Z |
| publishDate | 2016 |
| publisher | Massachusetts Medical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-503532017-10-19T12:26:05Z http://irep.iium.edu.my/50353/ Cholesterol lowering in intermediate-risk persons without cardiovascular disease Yusuf, Salim Bosch, Jackie Dagenais, Gilles Jun, Zhu Xavier, Denis Lisheng, Liu Md Aris, Mohd Aznan Mohd Shah, Azarisman Shah ., et. al R Medicine (General) RC Internal medicine RJ Pediatrics RZ Other systems of medicine Previous trials have shown that the use of statins to lower cholesterol reduces the risk of cardiovascular events among persons without cardiovascular disease. Those trials have involved persons with elevated lipid levels or inflammatory markers and involved mainly white persons. It is unclear whether the benefits of statins can be extended to an intermediate-risk, ethnically diverse population without cardiovascular disease. In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants in 21 countries who did not have cardiovascular disease and were at intermediate risk to receive rosuvastatin at a dose of 10 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, and the second coprimary outcome additionally included revascularization, heart failure, and resuscitated cardiac arrest. The median follow-up was 5.6 years. Massachusetts Medical Society 2016-04-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/50353/7/Cholesterol_Lowering_in_Intermediate-Risk.pdf application/pdf en http://irep.iium.edu.my/50353/11/DR_AZNAN.pdf Yusuf, Salim and Bosch, Jackie and Dagenais, Gilles and Jun, Zhu and Xavier, Denis and Lisheng, Liu and Md Aris, Mohd Aznan and Mohd Shah, Azarisman Shah and ., et. al (2016) Cholesterol lowering in intermediate-risk persons without cardiovascular disease. New England Journal of Medicine, 374 (21). pp. 2021-2031. ISSN 0028-4793 E-ISSN 1533-4406 htpp://www.nejm.orl.com 10.1056/NEJMoa1600176 |
| spellingShingle | R Medicine (General) RC Internal medicine RJ Pediatrics RZ Other systems of medicine Yusuf, Salim Bosch, Jackie Dagenais, Gilles Jun, Zhu Xavier, Denis Lisheng, Liu Md Aris, Mohd Aznan Mohd Shah, Azarisman Shah ., et. al Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title | Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title_full | Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title_fullStr | Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title_full_unstemmed | Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title_short | Cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| title_sort | cholesterol lowering in intermediate-risk persons without cardiovascular disease |
| topic | R Medicine (General) RC Internal medicine RJ Pediatrics RZ Other systems of medicine |
| url | http://irep.iium.edu.my/50353/ http://irep.iium.edu.my/50353/ http://irep.iium.edu.my/50353/ http://irep.iium.edu.my/50353/7/Cholesterol_Lowering_in_Intermediate-Risk.pdf http://irep.iium.edu.my/50353/11/DR_AZNAN.pdf |