Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study
During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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2016
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| Online Access: | http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf |
| _version_ | 1848783495095123968 |
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| author | Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa |
| author_facet | Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa |
| author_sort | Abu Bakar, Noraini |
| building | IIUM Repository |
| collection | Online Access |
| description | During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and cytokines, responsible for connective tissue remodeling (Nishijima Y et al 2006). Leptin, a polypeptide hormone has been classified as a cytokine (Zhang et al 1994). Earlier findings suggested that leptin does play a significant role in bone formation by its direct effect on osteoblasts (Alparslan et al 2010). This pilot study aimed to study leptin in saliva and its association with tooth movement during initial orthodontic alignment.
To determine if there is any difference in saliva leptin level before and after orthodontic alignment
Ten orthodontic patients (7 girls and 3 boys; mean age, 16.76 ± 1.1 years) with crowding (up to 5mm) that required orthodontic fixed appliances, on a non-extraction basis as part of the treatment plan, were recruited in this longitudinal study. Orthodontic study models were constructed at baseline and at 6-weeks after orthodontic treatment commenced. Full fixed orthodontic appliances with initial 0.014” Nickel Titanium archwire placed. The amount of crowding was measured, before and after initial alignment. Unstimulated morning saliva sample were collected at all visits, after at least an 8-hour period of fasting and no-toothbrushing. The samples were tested using Leptin Abnova LEP Human ELISA kit and subsequently analyzed.
Leptin concentration in saliva was significantly decreased in a time-dependant manner (p<0.001), from before orthodontic treatment (7016.45±425.15 pg/mL) and 6 weeks after bond-up (4901.92±238.64 pg/mL).
Leptin concentration in saliva is decreased during orthodontic tooth movement in initial alignment stage. |
| first_indexed | 2025-11-14T16:22:15Z |
| format | Proceeding Paper |
| id | iium-49656 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:22:15Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-496562018-05-24T01:15:27Z http://irep.iium.edu.my/49656/ Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa RK Dentistry During orthodontic tooth movement, the early response of periodontal tissues to mechanical stress is an acute inflammatory reaction. Mechanical stress from orthodontic appliances is believed to induce cells in the periodontal ligament (PDL) to form biologically active substances, such as enzymes and cytokines, responsible for connective tissue remodeling (Nishijima Y et al 2006). Leptin, a polypeptide hormone has been classified as a cytokine (Zhang et al 1994). Earlier findings suggested that leptin does play a significant role in bone formation by its direct effect on osteoblasts (Alparslan et al 2010). This pilot study aimed to study leptin in saliva and its association with tooth movement during initial orthodontic alignment. To determine if there is any difference in saliva leptin level before and after orthodontic alignment Ten orthodontic patients (7 girls and 3 boys; mean age, 16.76 ± 1.1 years) with crowding (up to 5mm) that required orthodontic fixed appliances, on a non-extraction basis as part of the treatment plan, were recruited in this longitudinal study. Orthodontic study models were constructed at baseline and at 6-weeks after orthodontic treatment commenced. Full fixed orthodontic appliances with initial 0.014” Nickel Titanium archwire placed. The amount of crowding was measured, before and after initial alignment. Unstimulated morning saliva sample were collected at all visits, after at least an 8-hour period of fasting and no-toothbrushing. The samples were tested using Leptin Abnova LEP Human ELISA kit and subsequently analyzed. Leptin concentration in saliva was significantly decreased in a time-dependant manner (p<0.001), from before orthodontic treatment (7016.45±425.15 pg/mL) and 6 weeks after bond-up (4901.92±238.64 pg/mL). Leptin concentration in saliva is decreased during orthodontic tooth movement in initial alignment stage. 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf application/pdf en http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf Abu Bakar, Noraini and Mustafa Al-Ahmad, Basma Ezzat and Hilal Abbood Al-Bayati, Lina and Kamil, Wisam Alaa (2016) Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study. In: International Orthodontic Conference SLOS 2016, 4-8 Feb 2016, Colombo,Sri Lanka. (Unpublished) http://www.srilankanentertainer.com/sri-lanka-events/international-orthodontic-conference-slos-2016-sri-lanka/ |
| spellingShingle | RK Dentistry Abu Bakar, Noraini Mustafa Al-Ahmad, Basma Ezzat Hilal Abbood Al-Bayati, Lina Kamil, Wisam Alaa Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title | Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title_full | Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title_fullStr | Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title_full_unstemmed | Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title_short | Saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| title_sort | saliva leptin levels in tooth movement during initial stage of orthodontic alignment : a pilot study |
| topic | RK Dentistry |
| url | http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/ http://irep.iium.edu.my/49656/4/IMG_20160212_0003.pdf http://irep.iium.edu.my/49656/9/Sri_Lanka.pdf |