Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum
Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities ag...
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Journal of Applied Pharmaceutical Science
2016
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| Online Access: | http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf |
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| author | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden |
| author_facet | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden |
| author_sort | Aminudin, Nurul Iman |
| building | IIUM Repository |
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| description | Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 μg/mL and A-549 at 26.41μg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125μg/mL and 62.5μg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals |
| first_indexed | 2025-11-14T16:22:00Z |
| format | Article |
| id | iium-49565 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:22:00Z |
| publishDate | 2016 |
| publisher | Journal of Applied Pharmaceutical Science |
| recordtype | eprints |
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| spelling | iium-495652016-12-22T00:16:40Z http://irep.iium.edu.my/49565/ Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden RS Pharmacy and materia medica Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 μg/mL and A-549 at 26.41μg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125μg/mL and 62.5μg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals Journal of Applied Pharmaceutical Science 2016-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf application/pdf en http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Rezauden (2016) Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum. Journal of Applied Pharmaceutical Science, 6 (1). pp. 23-27. ISSN 2231-3354 http://www.japsonline.com/admin/php/uploads/1743_pdf.pdf 10.7324/JAPS.2016.600104 |
| spellingShingle | RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Mohamed Zulkifli, Rezauden Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title | Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title_full | Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title_fullStr | Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title_full_unstemmed | Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title_short | Cytotoxic and antibacterial evaluation of coumarins and chromanone acid from Calophyllum symingtonianum |
| title_sort | cytotoxic and antibacterial evaluation of coumarins and chromanone acid from calophyllum symingtonianum |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/ http://irep.iium.edu.my/49565/1/2016-paper_Iman.pdf http://irep.iium.edu.my/49565/4/49565_Cytotoxic%20and%20antibacterial%20evaluation_scopus.pdf |