Group-based quantitative structure-activity relationship (G-QSAR) analysis and molecular docking of B-cell lymphoma two (BCL-2) inhibitors

QR Code

Group-based quantitative structure-activity relationship (G-QSAR) analysis and molecular docking of B-cell lymphoma two (BCL-2) inhibitors

Bcl-2 is the founding protein of Bcl-2 family and it is one of the inner mitochondrial membrane protein which acts as inhibitor of apoptosis, prolong cell survivals and regulate cell death negatively. Bcl-2 has been reported by previous study that it has significant percentage to be presented in man...

Full description

Bibliographic Details
Main Authors:	Abdul Samat, Nadia Hanis, Mohamed, Farahidah, Abdullahi , Abubakar
Format:	Article
Language:	English
Published:	Akademi Sains Malaysia and Confederation of Scientific & Technological Association in Malaysia (COSTAM) 2013
Subjects:	QD Chemistry RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/49054/ http://irep.iium.edu.my/49054/4/49054.pdf

Similar Items

Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation
by: Wong, K. K. V., et al.
Published: (2023)

Molecular docking of selected flavonoid compounds from nelumbo nucifera as potential pancreatic lipase inhibitor
by: Ghazali, Siti Nur Akmal, et al.
Published: (2017)

Group- based quantitative structural activity relationship analysis of B-cell Lymphoma Extra Large (BCL-XL) inhibitors
by: Abdul Samat, Nadia Hanis, et al.
Published: (2014)

Potential lipase inhibitor for obesity treatment
by: Alias, Norsyuhada, et al.
Published: (2015)

Rosmarinic acid as pancreatic lipase inhibitor
by: Raja Abd. Rahman, Raja Noor Zaliha, et al.
Published: (2016)

The effect of Nigella sativa extract on mouse oocyte activation
by: Abdul Rahman, Suzanah, et al.
Published: (2014)

A pioneer experience in Malaysia on In-house Radio-labelling of 131I-rituximab in the treatment of Non-Hodgkin's Lymphoma and a case report of high dose 131I-rituximab-BEAM conditioning autologous transplant
by: Jew, Win Kuan, et al.
Published: (2016)

Cytotoxicity of Clinacanthus Nutans Extracts on Human Hepatoma (HepG2) Cell Line
by: Hazrulrizawati, Hamid, et al.
Published: (2016)

Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA
by: Mohd F. F., Mohd Aluwi, et al.
Published: (2019)

Differential patterns of adherence to opioid therapy in opioid naïve and opioid existing patients with different age groups
by: Zin, Che Suraya, et al.
Published: (2019)

Characterization study of inggu (ferula asafetida) resin
by: Zulkply, Siti Mariam, et al.
Published: (2014)

Antibiotic use among hospitalized patients in northern Nigeria: a multicenter point- prevalence survey
by: Abubakar, Usman
Published: (2020)

Compliance with surgical antibiotic prophylaxis for obstetric and gynecologic surgeries in Nigeria: a retrospective study
by: Abubakar, Usman
Published: (2019)

Compatibility characterization of Gentamicin-Nigella sativa fusion as a future greener pharmaceutical intended for ortheopaedic infection
by: Harun Ismail, Ahmad Fahmi, et al.
Published: (2014)

Preparation and characterization of gentamicin-nigella sativa oil fusion microemulsions for future greener pharmaceutical
by: Mohd Nor, Nurul Hafizah, et al.
Published: (2014)

Nationwide survey of Pharmacist’s involvement in antimicrobial stewardship program in Nigerian Tertiary Hospitals
by: Abubakar, Usman, et al.
Published: (2019)

In vitro antimicrobial effect of Gentamicin-N.sativa fusion emulsion against biofilm producing strain S.aureus, P.aeruginosa and S.epidermidis
by: Yaacob, Khairul Ikhwan, et al.
Published: (2014)

Formulation and stability testing of gentamicin-Nigella sativa emulsions for osteo-healing application
by: Yusof, Fathin Athirah, et al.
Published: (2014)

The chemopreventive effects of Nigella sativa extract and Thymoquinone in a paternal toxicity study
by: Abdul Samat, Nadia Hanis, et al.
Published: (2015)

Influence of multiple variables on characteristics of “Neurobionanoparticles” prepared by diffusion-solvent-evaporation technique
by: Mansor, Nur 'Izzati, et al.
Published: (2012)

Prevalence and predictors of antibiotic use among children visiting the Emergency Department in a tertiary hospital in Malaysia
by: Tham, Daniel Wai Je, et al.
Published: (2020)

Screening of the antifungal activity of Andrographis paniculata on Candida albicans and Trichophyton mentagrophytes
by: Sule, Abubakar, et al.
Published: (2010)

Spectrophotometric determination of gentamicin loaded PLGA microparticles and method validation via ninhydrin-gentamicin complex as a rapid quantification approach
by: Harun @ Ismail, Ahmad Fahmi, et al.
Published: (2016)

Bacteriostatic and bactericidal activities of Andrographis paniculata extracts on skin disease causing pathogenic bacteria
by: Ahmed, Qamar Uddin, et al.
Published: (2011)

Screening for antibacterial activity of Andrographis paniculata used in Malaysian folkloric medicine: a possible alternative for the treatment of skin infections
by: Sule, Abubakar, et al.
Published: (2010)

Cytotoxicity study of newly-synthesized carbonyl thiourea derivatives on pathogenic Acanthamoeba and its quantitative structure-activity relationship (QSAR) analysis
by: Ibrahim, Maizatul Akma, et al.
Published: (2016)

Efficiency of Polyphenol Extraction from Artificial Honey Using C18 Cartridges and Amberlite„ XAD-2 Resin: A Comparative Study
by: Chua, Yung An, et al.
Published: (2016)

Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract
by: Khalil, Md. Ibrahim, et al.
Published: (2015)

Synthesis, in-vitro and in silico studies of azo-based calix[4]arenes as antibacterial agent and neuraminidase inhibitor: a new look into an old scaffold
by: Ali, Yousaf, et al.
Published: (2018)

Short-term effects of TAF 273 on oestrous cycle and reproductive hormones of normal rats
by: Ahmad, Nur Amalina, et al.
Published: (2015)

Genetic diversity and natural selection of the rhoptry-associated protein 1 (RAP-1) of recent Plasmodium knowlesi clinical isolates from Malaysia / Mira Syahfriena Amir Rawa
by: Mira Syahfriena , Amir Rawa
Published: (2016)

Biological activities of Curcuma purpurascens BI. Rhizome extract using in vitro and in vivo models / Elham Rouhollahi
by: Elham, Rouhollahi
Published: (2016)

Dose-and time dependent effects of oil-palm (Elaeis guineensis) leaf extract in streptozocin-induced oxidative stress and renal damage in diabetic rats / Varatharajan Rajavel
by: Vatharajan, Rajavel
Published: (2016)

In ViVo anti-malarial activity of some Malaysian traditional plants: Community's awareness and ethnobotanical survey / Abdulelah Hussien Ahmed Al-Adhroey
by: Abdulelah Hussien, Ahmed Al-Adhroey
Published: (2011)

Effect of royal jelly on male infertility
by: E. Al-Sanafi, Ali, et al.
Published: (2007)

Toxicological profiles of Carbamazepine, Gabapentin and their combination at high therapeutic doses in rat
by: Abdullah, Sinan Mohammed, et al.
Published: (2014)

Histopathological changes of the cardiac muscle and the adrenal gland in long term diabetic rat
by: Abdullah, Sinan Mohammed, et al.
Published: (2014)

Our students are they healthy?
by: Mohd Rashid, Muhammad Hakimi, et al.
Published: (2014)

Cardiovascular risks profile in young non-smoker male IIUM students in Kuantan campus
by: Mohd Rashid, Muhammad Hakimi, et al.
Published: (2014)

Pharmacokinetics of meropenem in critically ill patients receiving continuous venovenous haemofiltration: A randomized controlled trial of continuous infusion versus intermittent bolus administration
by: Jamal, Janattul-Ain, et al.
Published: (2015)