Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats
Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors....
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://irep.iium.edu.my/48151/ http://irep.iium.edu.my/48151/1/716532.pdf |
| _version_ | 1848783253817786368 |
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| author | Ismail, Azlini Mohamed, M. Sulaiman, Siti Amrah Wan Ahmad, W. A. N. |
| author_facet | Ismail, Azlini Mohamed, M. Sulaiman, Siti Amrah Wan Ahmad, W. A. N. |
| author_sort | Ismail, Azlini |
| building | IIUM Repository |
| collection | Online Access |
| description | Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia ( |
| first_indexed | 2025-11-14T16:18:25Z |
| format | Article |
| id | iium-48151 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:18:25Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-481512016-07-15T06:18:14Z http://irep.iium.edu.my/48151/ Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats Ismail, Azlini Mohamed, M. Sulaiman, Siti Amrah Wan Ahmad, W. A. N. RM Therapeutics. Pharmacology RS Pharmacy and materia medica Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia ( Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/48151/1/716532.pdf Ismail, Azlini and Mohamed, M. and Sulaiman, Siti Amrah and Wan Ahmad, W. A. N. (2013) Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats. Evidence-Based Complementary and Alternative Medicine, 2013. pp. 1-16. ISSN 1741-427X E-ISSN 1741-4288 http://dx.doi.org/10.1155/2013/716532 10.1155/2013/716532 |
| spellingShingle | RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ismail, Azlini Mohamed, M. Sulaiman, Siti Amrah Wan Ahmad, W. A. N. Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title | Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title_full | Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title_fullStr | Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title_full_unstemmed | Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title_short | Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats |
| title_sort | autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of syzygium polyanthum(wight) walp.var.polyanthum leaves in anaesthetized rats |
| topic | RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/48151/ http://irep.iium.edu.my/48151/ http://irep.iium.edu.my/48151/ http://irep.iium.edu.my/48151/1/716532.pdf |