Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals
Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for ev...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015
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| Online Access: | http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf |
| _version_ | 1848783204661592064 |
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| author | Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina |
| author_facet | Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina |
| author_sort | Yusof, Faridah |
| building | IIUM Repository |
| collection | Online Access |
| description | Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this
study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase
NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating
kidney damage.
Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study.
Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by
spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the
government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.
Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in
patients compared to control group. Compared with control subjects, activities and specific activities of
serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01).
Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3
SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients
with nephrolithiasis. |
| first_indexed | 2025-11-14T16:17:38Z |
| format | Article |
| id | iium-47808 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:17:38Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-478082018-05-23T01:57:51Z http://irep.iium.edu.my/47808/ Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina R Medicine (General) Objective Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage. Methods Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria. Results The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P<0.01). Conclusion This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis. Elsevier 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf Yusof, Faridah and Mehde, Atheer Awad and Mehdi, Wesen Adel and Ahmad Raus, Raha and Ghazali, Hamid and Abdul Rahman, Azlina (2015) Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals. Biomedical and Environmental Science, 28 (9). pp. 660-665. ISSN 0895-3988 http://www.journals.elsevier.com/biomedical-and-environmental-sciences/ |
| spellingShingle | R Medicine (General) Yusof, Faridah Mehde, Atheer Awad Mehdi, Wesen Adel Ahmad Raus, Raha Ghazali, Hamid Abdul Rahman, Azlina Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title | Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title_full | Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title_fullStr | Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title_full_unstemmed | Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title_short | Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian individuals |
| title_sort | effects of nephrolithiasis on serum dnase (deoxyribonuclease i and ii) activity and e3 sumo-protein ligase nse2 (nsmce2) in malaysian individuals |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/ http://irep.iium.edu.my/47808/1/Atheer_Biomed_Environ_Sci_2015.pdf |