Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
The purpose of this study was to fabricate insulin-loaded double-walled and singlepolymer poly(lactide-co-glycolide) (PLGA) microspheres using a fast degrading glucose core, hydroxyl-terminated poly(lactide-co-glycolide) (Glu-PLGA) and a moderate degrading carboxyl-terminated PLGA polymers. A modifi...
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| Format: | Article |
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Springer
2016
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| Online Access: | http://irep.iium.edu.my/47774/ http://irep.iium.edu.my/47774/1/Mokhles-DDTR-D-15-00072_R1.pdf http://irep.iium.edu.my/47774/4/47774_Preparation%2C%20characterization_wos_scopus.pdf |
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| author | Ansary, Md. Rezaul Haque Rahman, Md. Mokhlesur Awang, Mohamed Katas, Haliza Ab. Hadi, Hazrina Abd Almonem, Doolaanea |
| author_facet | Ansary, Md. Rezaul Haque Rahman, Md. Mokhlesur Awang, Mohamed Katas, Haliza Ab. Hadi, Hazrina Abd Almonem, Doolaanea |
| author_sort | Ansary, Md. Rezaul Haque |
| building | IIUM Repository |
| collection | Online Access |
| description | The purpose of this study was to fabricate insulin-loaded double-walled and singlepolymer poly(lactide-co-glycolide) (PLGA) microspheres using a fast degrading glucose core, hydroxyl-terminated poly(lactide-co-glycolide) (Glu-PLGA) and a moderate degrading carboxyl-terminated PLGA polymers. A modified water-in-oil-in-oilin-water (w/o/o/w) emulsion solvent evaporation technique was employed to prepare double-walled microspheres, whereas single-polymer microspheres were fabricated by a conventional water-in-oil-in-water (w/o/w) emulsion solvent evaporation method. The effect of fabrication techniques and polymer characteristics on microspheres size,morphology, encapsulation efficiency, in vitro release and insulin stability were evaluated. The prepared double-walled microspheres were essentially non-porous,smooth surfaced, and spherical in shape, whereas single-polymer microspheres were highly porous. Double-walled microspheres exhibited a significantly reduced initial burst followed by sustained and almost complete release of insulin compared to singlepolymer microspheres. Initial burst release was further suppressed from double-walled microspheres when the mass ratio of the component polymers was increased. In conclusion, double-walled microspheres made of Glu-PLGA and PLGA can be a potential delivery system of therapeutic insulin. |
| first_indexed | 2025-11-14T16:17:34Z |
| format | Article |
| id | iium-47774 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:17:34Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-477742017-03-20T04:11:57Z http://irep.iium.edu.my/47774/ Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres Ansary, Md. Rezaul Haque Rahman, Md. Mokhlesur Awang, Mohamed Katas, Haliza Ab. Hadi, Hazrina Abd Almonem, Doolaanea QD Chemistry The purpose of this study was to fabricate insulin-loaded double-walled and singlepolymer poly(lactide-co-glycolide) (PLGA) microspheres using a fast degrading glucose core, hydroxyl-terminated poly(lactide-co-glycolide) (Glu-PLGA) and a moderate degrading carboxyl-terminated PLGA polymers. A modified water-in-oil-in-oilin-water (w/o/o/w) emulsion solvent evaporation technique was employed to prepare double-walled microspheres, whereas single-polymer microspheres were fabricated by a conventional water-in-oil-in-water (w/o/w) emulsion solvent evaporation method. The effect of fabrication techniques and polymer characteristics on microspheres size,morphology, encapsulation efficiency, in vitro release and insulin stability were evaluated. The prepared double-walled microspheres were essentially non-porous,smooth surfaced, and spherical in shape, whereas single-polymer microspheres were highly porous. Double-walled microspheres exhibited a significantly reduced initial burst followed by sustained and almost complete release of insulin compared to singlepolymer microspheres. Initial burst release was further suppressed from double-walled microspheres when the mass ratio of the component polymers was increased. In conclusion, double-walled microspheres made of Glu-PLGA and PLGA can be a potential delivery system of therapeutic insulin. Springer 2016-04-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/47774/1/Mokhles-DDTR-D-15-00072_R1.pdf application/pdf en http://irep.iium.edu.my/47774/4/47774_Preparation%2C%20characterization_wos_scopus.pdf Ansary, Md. Rezaul Haque and Rahman, Md. Mokhlesur and Awang, Mohamed and Katas, Haliza and Ab. Hadi, Hazrina and Abd Almonem, Doolaanea (2016) Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres. Drug Delivery and Translational Research. pp. 1-11. ISSN 2190-393X E-ISSN 2190-3948 http://link.springer.com/article/10.1007%2Fs13346-016-0278-y 10.1007/s13346-016-0278-y |
| spellingShingle | QD Chemistry Ansary, Md. Rezaul Haque Rahman, Md. Mokhlesur Awang, Mohamed Katas, Haliza Ab. Hadi, Hazrina Abd Almonem, Doolaanea Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title | Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full | Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_fullStr | Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full_unstemmed | Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_short | Preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_sort | preparation, characterization and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/47774/ http://irep.iium.edu.my/47774/ http://irep.iium.edu.my/47774/ http://irep.iium.edu.my/47774/1/Mokhles-DDTR-D-15-00072_R1.pdf http://irep.iium.edu.my/47774/4/47774_Preparation%2C%20characterization_wos_scopus.pdf |