Ion-selective electrode biochip for applications in a liquid environment
Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurem...
| Main Authors: | , , , , , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
Springer
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf |
| _version_ | 1848783106530607104 |
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| author | Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. |
| author2 | Ibrahim, Fatimah |
| author_facet | Ibrahim, Fatimah Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. |
| author_sort | Wan Salim, Wan Wardatul Amani |
| building | IIUM Repository |
| collection | Online Access |
| description | Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurements were performed in a custom-made flow-cell chamber. The results of potentiometric measurement of cationic analytes demonstrate the electrodes to have a near-Nernstian slope profile even after they are stored for almost a month in liquid medium. The electrodes also achieved H2O2 amperometric sensitivity (1.25 and 3.32 µAmM-1cm-2 for PEDOT:PSS and PEDOT:CaSO4 respectively) and lower detection limit (2.21 µM, 8.4 µM, 3.44 µM, for H+, NH4+, Ca2+ respectively) comparable to that of wire-type electrodes. Furthermore, the lifetime is dependent on the electrodeposition method of the conductive polymer, and the transducer layer must be modified to fit the analyte types. These results indicate that extended lifetime of microfabricated ion-selective electrodes in a multiplex format can be realized by optimizing the microfabricated electrode surface functionalization. |
| first_indexed | 2025-11-14T16:16:05Z |
| format | Proceeding Paper |
| id | iium-47221 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:16:05Z |
| publishDate | 2016 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-472212017-10-20T04:10:54Z http://irep.iium.edu.my/47221/ Ion-selective electrode biochip for applications in a liquid environment Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. T Technology (General) Physiological sensing conducted in a liquid environment requires electrodes with long lifetime. The development of a robust ion-selective electrode–based biochip in a lab-on-a-chip platform is described. To compare electrode lifetime, which is driven by the transducer layer, electrochemical measurements were performed in a custom-made flow-cell chamber. The results of potentiometric measurement of cationic analytes demonstrate the electrodes to have a near-Nernstian slope profile even after they are stored for almost a month in liquid medium. The electrodes also achieved H2O2 amperometric sensitivity (1.25 and 3.32 µAmM-1cm-2 for PEDOT:PSS and PEDOT:CaSO4 respectively) and lower detection limit (2.21 µM, 8.4 µM, 3.44 µM, for H+, NH4+, Ca2+ respectively) comparable to that of wire-type electrodes. Furthermore, the lifetime is dependent on the electrodeposition method of the conductive polymer, and the transducer layer must be modified to fit the analyte types. These results indicate that extended lifetime of microfabricated ion-selective electrodes in a multiplex format can be realized by optimizing the microfabricated electrode surface functionalization. Springer Ibrahim, Fatimah Usman, Juliana Mohktar, Mas Sahidayana Ahmad, Mohd Yazed 2016 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf Wan Salim, Wan Wardatul Amani and Hermann, Andrew C. and Zietchek, Michael Z. and Pfluger, Jonathan P. and Park, Joon H. and ul Haque, Aeraj and Sanober, Fahmi and Porterfield, Marshall D. (2016) Ion-selective electrode biochip for applications in a liquid environment. In: International Conference for Innovation in Biomedical Engineering and Life Sciences (ICIBEL2015), 6 - 8 December 2015, Putrajaya, Malaysia. http://www.springer.com/series/7403 10.1007/978-981-10-0266-3_18 |
| spellingShingle | T Technology (General) Wan Salim, Wan Wardatul Amani Hermann, Andrew C. Zietchek, Michael Z. Pfluger, Jonathan P. Park, Joon H. ul Haque, Aeraj Sanober, Fahmi Porterfield, Marshall D. Ion-selective electrode biochip for applications in a liquid environment |
| title | Ion-selective electrode biochip for applications in a liquid environment |
| title_full | Ion-selective electrode biochip for applications in a liquid environment |
| title_fullStr | Ion-selective electrode biochip for applications in a liquid environment |
| title_full_unstemmed | Ion-selective electrode biochip for applications in a liquid environment |
| title_short | Ion-selective electrode biochip for applications in a liquid environment |
| title_sort | ion-selective electrode biochip for applications in a liquid environment |
| topic | T Technology (General) |
| url | http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/ http://irep.iium.edu.my/47221/7/47221_Ion-selective%20electrode%20biochip%20for%20applications_SCOPUS.pdf http://irep.iium.edu.my/47221/13/47221_Ion-selective%20electrode%20biochip%20for%20applications%20in%20a%20liquid%20environment.pdf |