Relationship between metabolites composition and biological activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction
The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 an...
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| Format: | Article |
| Language: | English |
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Springer
2015
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| Online Access: | http://irep.iium.edu.my/46214/ http://irep.iium.edu.my/46214/1/mediani_et_al_2015.pdf |
| _version_ | 1848782926635859968 |
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| author | Mediani, Ahmed Abas, Faridah Khatib, Alfi Ching, Ping Tan Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin |
| author_facet | Mediani, Ahmed Abas, Faridah Khatib, Alfi Ching, Ping Tan Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin |
| author_sort | Mediani, Ahmed |
| building | IIUM Repository |
| collection | Online Access |
| description | The study investigated the changes in the metabolite,
antioxidant and α-glucosidase inhibitory activities of
Phyllanthus niruri after three drying treatments: air, freeze
and oven dryings. Water extracts and extracts obtained
using different solvent ratios of ethanol and methanol (50,
70, 80 and 100 %) were compared. The relationships
among the antioxidant, α-glucosidase inhibitory activity
and metabolite levels of the extracts were evaluated using
partial least-square analysis (PLS). The solvent selectivity
was assessed based on the phytochemical constituents present
in the extract and their concentrations quantitatively
analyzed using high performance liquid chromatography.
The freeze-dried P. niruri samples that were extracted with
the mixture of ethanol or methanol with low ratio of water
showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different
ratio and water extracts demonstrated that phenolic
acids (chlorogenic acid and ellagic acid) and flavonoids
were highly linked to strong α-glucosidase inhibitory and
antioxidant activities. |
| first_indexed | 2025-11-14T16:13:13Z |
| format | Article |
| id | iium-46214 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:13:13Z |
| publishDate | 2015 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-462142017-08-04T07:15:26Z http://irep.iium.edu.my/46214/ Relationship between metabolites composition and biological activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction Mediani, Ahmed Abas, Faridah Khatib, Alfi Ching, Ping Tan Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin Q Science (General) The study investigated the changes in the metabolite, antioxidant and α-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100 %) were compared. The relationships among the antioxidant, α-glucosidase inhibitory activity and metabolite levels of the extracts were evaluated using partial least-square analysis (PLS). The solvent selectivity was assessed based on the phytochemical constituents present in the extract and their concentrations quantitatively analyzed using high performance liquid chromatography. The freeze-dried P. niruri samples that were extracted with the mixture of ethanol or methanol with low ratio of water showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different ratio and water extracts demonstrated that phenolic acids (chlorogenic acid and ellagic acid) and flavonoids were highly linked to strong α-glucosidase inhibitory and antioxidant activities. Springer 2015-02-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46214/1/mediani_et_al_2015.pdf Mediani, Ahmed and Abas, Faridah and Khatib, Alfi and Ching, Ping Tan and Ismail, Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nordin (2015) Relationship between metabolites composition and biological activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction. Plant Foods for Human Nutrition, 70 (2). pp. 184-192. ISSN 1573-9104 (O), 0921-9668 (P) http://link.springer.com/article/10.1007%2Fs11130-015-0478-5 10.1007/s11130-015-0478-5 |
| spellingShingle | Q Science (General) Mediani, Ahmed Abas, Faridah Khatib, Alfi Ching, Ping Tan Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin Relationship between metabolites composition and biological activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title | Relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_full | Relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_fullStr | Relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_full_unstemmed | Relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_short | Relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| title_sort | relationship between metabolites composition and biological
activities of phyllanthus niruri extracts prepared by different drying methods and solvents extraction |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/46214/ http://irep.iium.edu.my/46214/ http://irep.iium.edu.my/46214/ http://irep.iium.edu.my/46214/1/mediani_et_al_2015.pdf |