Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine
Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical valu...
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Chiang Mai University
2016
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| Online Access: | http://irep.iium.edu.my/46121/ http://irep.iium.edu.my/46121/4/16-03-22-d490d.pdf http://irep.iium.edu.my/46121/7/46121_Synthesis%2C%20Characterization%20and%20Antioxidant%20Activity%20of%202-Halobenzoyl_Scopus.pdf http://irep.iium.edu.my/46121/13/46121_Synthesis%2C%20characterization%20and%20antioxidant%20activity_wos.pdf |
| _version_ | 1848782911046680576 |
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| author | Ngah, Nurziana Mohamed, Nor Azanita Darnis, Deny Susanti |
| author_facet | Ngah, Nurziana Mohamed, Nor Azanita Darnis, Deny Susanti |
| author_sort | Ngah, Nurziana |
| building | IIUM Repository |
| collection | Online Access |
| description | Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1 H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds. |
| first_indexed | 2025-11-14T16:12:58Z |
| format | Article |
| id | iium-46121 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T16:12:58Z |
| publishDate | 2016 |
| publisher | Chiang Mai University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-461212017-10-12T05:22:53Z http://irep.iium.edu.my/46121/ Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine Ngah, Nurziana Mohamed, Nor Azanita Darnis, Deny Susanti QD Chemistry Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1 H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds. Chiang Mai University 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/46121/4/16-03-22-d490d.pdf application/pdf en http://irep.iium.edu.my/46121/7/46121_Synthesis%2C%20Characterization%20and%20Antioxidant%20Activity%20of%202-Halobenzoyl_Scopus.pdf application/pdf en http://irep.iium.edu.my/46121/13/46121_Synthesis%2C%20characterization%20and%20antioxidant%20activity_wos.pdf Ngah, Nurziana and Mohamed, Nor Azanita and Darnis, Deny Susanti (2016) Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine. Chiang Mai Journal of Science, 43 (3). pp. 577-583. ISSN 0125-2526 http://it.science.cmu.ac.th/ejournal/journalDetail.php?journal_id=6816 |
| spellingShingle | QD Chemistry Ngah, Nurziana Mohamed, Nor Azanita Darnis, Deny Susanti Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title | Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title_full | Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title_fullStr | Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title_full_unstemmed | Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title_short | Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine |
| title_sort | synthesis, characterization and antioxidant activity of 2-halobenzoyl thiourea bearing α- and β-alanine |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/46121/ http://irep.iium.edu.my/46121/ http://irep.iium.edu.my/46121/4/16-03-22-d490d.pdf http://irep.iium.edu.my/46121/7/46121_Synthesis%2C%20Characterization%20and%20Antioxidant%20Activity%20of%202-Halobenzoyl_Scopus.pdf http://irep.iium.edu.my/46121/13/46121_Synthesis%2C%20characterization%20and%20antioxidant%20activity_wos.pdf |