Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers
Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Strept...
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| Format: | Article |
| Language: | English English |
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Malaysian Society of Parasitology and Tropical Medicine
2015
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| Online Access: | http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf http://irep.iium.edu.my/45269/2/Full_text.pdf |
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| author | Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida |
| author_facet | Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida |
| author_sort | Ahmad Yusof @ Hanafi, Hanani |
| building | IIUM Repository |
| collection | Online Access |
| description | Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Streptococcus pneumoniae among invasive, non-invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronate lyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronate lyase. Four hyaluronate lyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronate lyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronate lyase production in these isolates suggest their possible role as human pathogens. |
| first_indexed | 2025-11-14T16:10:35Z |
| format | Article |
| id | iium-45269 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:10:35Z |
| publishDate | 2015 |
| publisher | Malaysian Society of Parasitology and Tropical Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-452692015-10-21T07:05:49Z http://irep.iium.edu.my/45269/ Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida QR Microbiology Hyaluronate lyase produced by various microorganisms is capable of degrading hyaluronic acid in connective tissue and initiating spread of infection by opening an access for the pathogen into host tissues. The present study attempts to determine the distribution of hyaluronate lyase-producing Streptococcus pneumoniae among invasive, non-invasive and carriage isolates, and correlate it with the clinical sources, year of isolation, colonial morphology and their serotypes. A total of 100 isolates from various clinical samples were selected and screened for hyaluronate lyase production and presence of the encoding SpnHyl gene. All isolates possessed SpnHyl gene. Ninety-six isolates including 34 carriage isolates were positive for production of hyaluronate lyase. Four hyaluronate lyase-negative isolates were from blood (2 isolates) and sputum (2 isolates). No significant association was detected among hyaluronate lyase production and bacterial characteristics except for colonial morphology (p = 0.040). High percentages of hyaluronate lyase production in these isolates suggest their possible role as human pathogens. Malaysian Society of Parasitology and Tropical Medicine 2015 Article PeerReviewed application/pdf en http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf application/pdf en http://irep.iium.edu.my/45269/2/Full_text.pdf Ahmad Yusof @ Hanafi, Hanani and Mohd Desa, Mohd Nasir and Masri, Siti Norbaya and Osman, Malina and Jamal, Farida (2015) Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers. Tropical Biomedicine, 32 (3). pp. 1-12. ISSN 1239-5720 (In Press) http://www.msptm.org/journal.html |
| spellingShingle | QR Microbiology Ahmad Yusof @ Hanafi, Hanani Mohd Desa, Mohd Nasir Masri, Siti Norbaya Osman, Malina Jamal, Farida Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title | Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title_full | Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title_fullStr | Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title_full_unstemmed | Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title_short | Hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| title_sort | hyaluronate lyase production by streptococcus pneumoniae isolated from patients and carriers |
| topic | QR Microbiology |
| url | http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/ http://irep.iium.edu.my/45269/1/Acceptance_letter.pdf http://irep.iium.edu.my/45269/2/Full_text.pdf |