An empirical assessment of meta-analysis estimates from multi-level studies
A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the ove...
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2015
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| Online Access: | http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/1/IREP.pdf http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf |
| _version_ | 1848782753123794944 |
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| author | Misran, Nurul Afiqah Nik Idris, Nik Ruzni |
| author_facet | Misran, Nurul Afiqah Nik Idris, Nik Ruzni |
| author_sort | Misran, Nurul Afiqah |
| building | IIUM Repository |
| collection | Online Access |
| description | A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the overall estimates have not been fully explored. Objective: This study examined the efficacy of the estimates of overall treatment effect from AD, IPD and the mixed AD: IPD studies, and investigated how they differ from the true treatment effect. Additionally, this study investigated the influence of the ratio of AD: IPD on the precision of the overall treatment effects estimates. The bias, root mean-square-error (RMSE) and coverage probability were used to assess the efficiency of the overall estimates. Results: The results showed that the IPD meta-analysis produced better estimates in terms of RMSE compared to AD meta-analysis and the mixed AD:IPD meta-analysis. For the cases where both the AD and IPD studies were available, our findings showed that the combined AD : IPD data produced better estimates, in terms of precision, than utilising the AD alone. Conclusion: It is therefore recommended that available IPD should always be included in a conventional meta-analysis using summary level data as significant |
| first_indexed | 2025-11-14T16:10:28Z |
| format | Proceeding Paper |
| id | iium-45232 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:10:28Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-452322016-05-23T02:05:49Z http://irep.iium.edu.my/45232/ An empirical assessment of meta-analysis estimates from multi-level studies Misran, Nurul Afiqah Nik Idris, Nik Ruzni Q Science (General) A conventional meta-analysis may be performed using studies which are available at individual patient level (IPD) or aggregate level (AD). Presently however, meta-analysis that combine the two levels of studies is increasingly common. The implications of utilising different levels of data on the overall estimates have not been fully explored. Objective: This study examined the efficacy of the estimates of overall treatment effect from AD, IPD and the mixed AD: IPD studies, and investigated how they differ from the true treatment effect. Additionally, this study investigated the influence of the ratio of AD: IPD on the precision of the overall treatment effects estimates. The bias, root mean-square-error (RMSE) and coverage probability were used to assess the efficiency of the overall estimates. Results: The results showed that the IPD meta-analysis produced better estimates in terms of RMSE compared to AD meta-analysis and the mixed AD:IPD meta-analysis. For the cases where both the AD and IPD studies were available, our findings showed that the combined AD : IPD data produced better estimates, in terms of precision, than utilising the AD alone. Conclusion: It is therefore recommended that available IPD should always be included in a conventional meta-analysis using summary level data as significant 2015-10-15 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/45232/1/IREP.pdf application/pdf en http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf Misran, Nurul Afiqah and Nik Idris, Nik Ruzni (2015) An empirical assessment of meta-analysis estimates from multi-level studies. In: National Postgraduate Conference on Science and Technology (NPCST 2015), 9-10 Oct 2015, Melia Hotel, Kuala Lumpur. http://npcst2015.weebly.com/ |
| spellingShingle | Q Science (General) Misran, Nurul Afiqah Nik Idris, Nik Ruzni An empirical assessment of meta-analysis estimates from multi-level studies |
| title | An empirical assessment of meta-analysis estimates from multi-level studies |
| title_full | An empirical assessment of meta-analysis estimates from multi-level studies |
| title_fullStr | An empirical assessment of meta-analysis estimates from multi-level studies |
| title_full_unstemmed | An empirical assessment of meta-analysis estimates from multi-level studies |
| title_short | An empirical assessment of meta-analysis estimates from multi-level studies |
| title_sort | empirical assessment of meta-analysis estimates from multi-level studies |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/ http://irep.iium.edu.my/45232/1/IREP.pdf http://irep.iium.edu.my/45232/3/conference_program-_kuala_lumpur_oct-ver06.pdf |