Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA micro...
| Main Authors: | , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44964/ http://irep.iium.edu.my/44964/1/44964_abstract.pdf |
| _version_ | 1848782699383226368 |
|---|---|
| author | Rahman, Md. Mokhlesur Ansary, Rezaul Haque Katas, Haliza Ab. Hadi, Hazrina Mohamed, Awang |
| author_facet | Rahman, Md. Mokhlesur Ansary, Rezaul Haque Katas, Haliza Ab. Hadi, Hazrina Mohamed, Awang |
| author_sort | Rahman, Md. Mokhlesur |
| building | IIUM Repository |
| collection | Online Access |
| description | The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA microspheres. Double-walled microspheres were prepared by a modified water-in-oil-in-oil-in-water (w/o/o/w) emulsion solvent evaporation method. The prepared double-walled microspheres were non-porous, smooth surfaced, and spherical in shape. A significant reduction of the initial burst release of insulin was achieved from the prepared double-walled microspheres. Moreover, a sustained and complete release of insulin without any lag phase was achieved in this study. Thus, double-walled microspheres can be a potential delivery system of therapeutic insulin. |
| first_indexed | 2025-11-14T16:09:36Z |
| format | Proceeding Paper |
| id | iium-44964 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:09:36Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-449642017-10-12T02:37:49Z http://irep.iium.edu.my/44964/ Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres Rahman, Md. Mokhlesur Ansary, Rezaul Haque Katas, Haliza Ab. Hadi, Hazrina Mohamed, Awang QD Chemistry The aim of this study was to fabricate insulin-loaded double-walled poly(lactide-co-glycolide) (PLGA) microspheres using two different terminated PLGA (hydroxyl and carboxyl) to reduce the initial burst release as well as to remove the lag phase from the release profiles of insulin loaded PLGA microspheres. Double-walled microspheres were prepared by a modified water-in-oil-in-oil-in-water (w/o/o/w) emulsion solvent evaporation method. The prepared double-walled microspheres were non-porous, smooth surfaced, and spherical in shape. A significant reduction of the initial burst release of insulin was achieved from the prepared double-walled microspheres. Moreover, a sustained and complete release of insulin without any lag phase was achieved in this study. Thus, double-walled microspheres can be a potential delivery system of therapeutic insulin. 2015-12-19 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/44964/1/44964_abstract.pdf Rahman, Md. Mokhlesur and Ansary, Rezaul Haque and Katas, Haliza and Ab. Hadi, Hazrina and Mohamed, Awang (2015) Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres. In: Controlled Release & Drug Delivery Symposium 2014 (CRDDS 2015), 23rd-24th Aug. 2015, Kuala Lumpur Campus, Kuala Lumpur. (Unpublished) http://www.ukm.my/crdds/index.php/ |
| spellingShingle | QD Chemistry Rahman, Md. Mokhlesur Ansary, Rezaul Haque Katas, Haliza Ab. Hadi, Hazrina Mohamed, Awang Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title | Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full | Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_fullStr | Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_full_unstemmed | Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_short | Preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| title_sort | preparation, characterization and release profiles of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/44964/ http://irep.iium.edu.my/44964/ http://irep.iium.edu.my/44964/1/44964_abstract.pdf |