Development of generic gliclazide 60 mg modified release tablets using central composite design
A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2...
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| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacists of Buenos Aires Province, Argentina
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44848/ http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf |
| _version_ | 1848782678226108416 |
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| author | Elsayed, Tarek Mohamed Ali Mandal, Uttam Kumar Kasmuri, Abdul Razak |
| author_facet | Elsayed, Tarek Mohamed Ali Mandal, Uttam Kumar Kasmuri, Abdul Razak |
| author_sort | Elsayed, Tarek Mohamed Ali |
| building | IIUM Repository |
| collection | Online Access |
| description | A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a
drug retaining polymer was prepared by direct compression. Central composite design was adopted for
formulation optimization. The two independent formulation variables included the amount of Methocel®
K100 LV DC2 and Maltrin® M150, whereas the response variables were cumulative % drug release in 1,
2, 4, 8, and 12 h. Drug release data were fitted to various mathematical models for describing the release
mechanism from tablets. The effect of polymer and maltodextrin content on gliclazide release at different
time points were statistically evaluated by applying one-way ANOVA at 0.05. Four more formulas were
prepared to evaluate the prediction ability of the model. All the formulations showed a high correlation
coefficient (r2) with zero order and Korsmeyer-Peppas release mechanism. The actual cumulative % drug
release versus predicted of the evaluation formulations showed good model prediction with high similarity
(86-98) and low difference factors (1-3). |
| first_indexed | 2025-11-14T16:09:16Z |
| format | Article |
| id | iium-44848 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:09:16Z |
| publishDate | 2015 |
| publisher | College of Pharmacists of Buenos Aires Province, Argentina |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-448482017-10-31T11:06:34Z http://irep.iium.edu.my/44848/ Development of generic gliclazide 60 mg modified release tablets using central composite design Elsayed, Tarek Mohamed Ali Mandal, Uttam Kumar Kasmuri, Abdul Razak RS Pharmacy and materia medica A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2 and Maltrin® M150, whereas the response variables were cumulative % drug release in 1, 2, 4, 8, and 12 h. Drug release data were fitted to various mathematical models for describing the release mechanism from tablets. The effect of polymer and maltodextrin content on gliclazide release at different time points were statistically evaluated by applying one-way ANOVA at 0.05. Four more formulas were prepared to evaluate the prediction ability of the model. All the formulations showed a high correlation coefficient (r2) with zero order and Korsmeyer-Peppas release mechanism. The actual cumulative % drug release versus predicted of the evaluation formulations showed good model prediction with high similarity (86-98) and low difference factors (1-3). College of Pharmacists of Buenos Aires Province, Argentina 2015-06-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf Elsayed, Tarek Mohamed Ali and Mandal, Uttam Kumar and Kasmuri, Abdul Razak (2015) Development of generic gliclazide 60 mg modified release tablets using central composite design. Latin American Journal of Pharmacy, 34 (8). pp. 1516-1525. ISSN 2362-3853 http://www.latamjpharm.org/ |
| spellingShingle | RS Pharmacy and materia medica Elsayed, Tarek Mohamed Ali Mandal, Uttam Kumar Kasmuri, Abdul Razak Development of generic gliclazide 60 mg modified release tablets using central composite design |
| title | Development of generic gliclazide 60 mg modified
release tablets using central composite design |
| title_full | Development of generic gliclazide 60 mg modified
release tablets using central composite design |
| title_fullStr | Development of generic gliclazide 60 mg modified
release tablets using central composite design |
| title_full_unstemmed | Development of generic gliclazide 60 mg modified
release tablets using central composite design |
| title_short | Development of generic gliclazide 60 mg modified
release tablets using central composite design |
| title_sort | development of generic gliclazide 60 mg modified
release tablets using central composite design |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/44848/ http://irep.iium.edu.my/44848/ http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf |