The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet
Hypertension is one of the most important risk factors for cardiovascular events. It has become a sigaificant socioeconomic burden in many countries" Eurycoma longifolia (EL), Simaroubaceae, is a herb that has been used since ancient times to combat many health problems. Its effects are attr...
| Main Authors: | , , , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44749/ http://irep.iium.edu.my/44749/1/44749.pdf |
| _version_ | 1848782657914142720 |
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| author | Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Mokhtar, Rafidah Hanim Ku Zaifah, Norsidah |
| author_facet | Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Mokhtar, Rafidah Hanim Ku Zaifah, Norsidah |
| author_sort | Al-Joufi, Fakhria |
| building | IIUM Repository |
| collection | Online Access |
| description | Hypertension is one of the most important risk factors for cardiovascular events. It has become a
sigaificant socioeconomic burden in many countries" Eurycoma longifolia (EL), Simaroubaceae,
is a herb that has been used since ancient times to combat many health problems. Its effects are
attributed to its bioactive constituents. This study focused on the effects of EL on blood presswe
(BP) and body weight (BSD in rats fed high-fat (I{F). Healthy male SD rats wete randomly
divided into 4 groups (n:6) and were orally fed the following diets: 1) Normal diet alone (ND);
2) Normal diet plus EL [15 mdke] QID+EL); High-Fat diet (53%) alone (]IFD); High-Fat diet
(53%) plus EL [15 mglkg] (I{FD+EL). EL extract was oraliy administered for 12 weeks.
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at week 0, 6
and 72 by using CODA@ tail-cuff BP system while the BW was measured weekly. Statistical
significance was determined by repeated measure (ANOVA) and one-way (ANOVA). P values <
0.05 were considered significant. Administration of EL led to less increment in BW OrD (34%)
vs. NDEL (21%) and IIFD (37%) vs. IIFDEL (25%)) but did not achieve significant level. No
changes in SBP and DBP were demonstrated zlmong the experimental groups at week 0. In
addition, ND and NDEL groups did not show any significant difference in SBP and DBP (p >
0.05) over the period of the study. Although, the SBP and DBP were significantly increased in
IIFD and IIFDEL compared to ND $<0.05), the SBP and DPB were significantly reduced in
IIFDEL as compared with IIFD 1p: 0.001) over the period of study. This study showed that the
potential BW reduction effect of EL and its anti-hypertensive property by providing a significant
reduction in SBP and DBP" |
| first_indexed | 2025-11-14T16:08:57Z |
| format | Proceeding Paper |
| id | iium-44749 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:08:57Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-447492017-06-16T02:10:13Z http://irep.iium.edu.my/44749/ The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Mokhtar, Rafidah Hanim Ku Zaifah, Norsidah RM Therapeutics. Pharmacology Hypertension is one of the most important risk factors for cardiovascular events. It has become a sigaificant socioeconomic burden in many countries" Eurycoma longifolia (EL), Simaroubaceae, is a herb that has been used since ancient times to combat many health problems. Its effects are attributed to its bioactive constituents. This study focused on the effects of EL on blood presswe (BP) and body weight (BSD in rats fed high-fat (I{F). Healthy male SD rats wete randomly divided into 4 groups (n:6) and were orally fed the following diets: 1) Normal diet alone (ND); 2) Normal diet plus EL [15 mdke] QID+EL); High-Fat diet (53%) alone (]IFD); High-Fat diet (53%) plus EL [15 mglkg] (I{FD+EL). EL extract was oraliy administered for 12 weeks. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at week 0, 6 and 72 by using CODA@ tail-cuff BP system while the BW was measured weekly. Statistical significance was determined by repeated measure (ANOVA) and one-way (ANOVA). P values < 0.05 were considered significant. Administration of EL led to less increment in BW OrD (34%) vs. NDEL (21%) and IIFD (37%) vs. IIFDEL (25%)) but did not achieve significant level. No changes in SBP and DBP were demonstrated zlmong the experimental groups at week 0. In addition, ND and NDEL groups did not show any significant difference in SBP and DBP (p > 0.05) over the period of the study. Although, the SBP and DBP were significantly increased in IIFD and IIFDEL compared to ND $<0.05), the SBP and DPB were significantly reduced in IIFDEL as compared with IIFD 1p: 0.001) over the period of study. This study showed that the potential BW reduction effect of EL and its anti-hypertensive property by providing a significant reduction in SBP and DBP" 2015 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/44749/1/44749.pdf Al-Joufi, Fakhria and Saxena, Anil Kumar and Al-Ani, Imad Matloub Dally and A.Talib, Norlelawati and Mokhtar, Rafidah Hanim and Ku Zaifah, Norsidah (2015) The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet. In: 29th Scientific Meeting of Malaysian Society of Pharmacology and Physiolgy (MSPP), 24-25 August 2015, Setia City Convention Centre, Shah Alam, Malaysia. (Unpublished) http://medicine.uitm.edu.my/mspp2015/ |
| spellingShingle | RM Therapeutics. Pharmacology Al-Joufi, Fakhria Saxena, Anil Kumar Al-Ani, Imad Matloub Dally A.Talib, Norlelawati Mokhtar, Rafidah Hanim Ku Zaifah, Norsidah The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title | The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title_full | The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title_fullStr | The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title_full_unstemmed | The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title_short | The effect of oral administration of Eurycoma longifolia extract on body weight and blood pressure in Sprague dawley rats fed high-fat diet |
| title_sort | effect of oral administration of eurycoma longifolia extract on body weight and blood pressure in sprague dawley rats fed high-fat diet |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/44749/ http://irep.iium.edu.my/44749/ http://irep.iium.edu.my/44749/1/44749.pdf |