Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted...
| Main Authors: | , , , , , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/1/44594.pdf |
| _version_ | 1848782632181039104 |
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| author | Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed |
| author_facet | Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed |
| author_sort | Khatib, Alfi |
| building | IIUM Repository |
| collection | Online Access |
| description | Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol were employed. Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained loading scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different quality of samples. GCMS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. Through this approach several chemical makers e.g. catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified as an α-glucosidase inhibitors of this herb. |
| first_indexed | 2025-11-14T16:08:32Z |
| format | Proceeding Paper |
| id | iium-44594 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:08:32Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-445942016-08-10T03:56:52Z http://irep.iium.edu.my/44594/ Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Q Science (General) Cosmos caudatus (“Ulam Raja” in Malaysia) is a plant used in Malaysia to enhance vitality and has been studied for its antidiabetic activity. This study focused on the evaluation of the α-glucosidase inhibitory activity of different ethanolic extracts of C. caudatus. Six series of samples extracted with water, 20%, 40%, 60%, 80%, and 100% ethanol were employed. Gas chromatography-mass spectrometry (GC-MS) and multivariate data analysis was used to correlate bioactivity of different extracts to different metabolite profiles of C. caudatus. The obtained loading scores indicated a distinct and remarkable separation into 6 clusters, which were indicative of the 6 different quality of samples. GCMS can be integrated with multivariate data analysis to identify compounds that inhibit α-glucosidase activity. Through this approach several chemical makers e.g. catechin, α-linolenic acid, α-D-glucopyranoside, and vitamin E compounds were identified as an α-glucosidase inhibitors of this herb. 2015-08-24 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/44594/1/44594.pdf Khatib, Alfi and Javadi, Neda and Abas, Faridah and Abdul Hamid, Azizah and Simoh, Sanimah and Shaari, Khozirah and Ismail, Intan Safinar and Mediani, Ahmed (2015) Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics. In: 29th Scientific Meeting of Malaysian Society of Pharmacology and Physiolgy (MSPP), 24-25 August 2015, Setia City Convention Centre, Shah Alam, Malaysia. (Unpublished) http://medicine.uitm.edu.my/mspp2015/index.php/scientific-program/free-oral-communications-session-1 |
| spellingShingle | Q Science (General) Khatib, Alfi Javadi, Neda Abas, Faridah Abdul Hamid, Azizah Simoh, Sanimah Shaari, Khozirah Ismail, Intan Safinar Mediani, Ahmed Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title | Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title_full | Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title_fullStr | Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title_full_unstemmed | Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title_short | Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics |
| title_sort | identification of alpha-glucosidase inhibitors in cosmos caudatus leaves using gc-ms based metabolomics |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/ http://irep.iium.edu.my/44594/1/44594.pdf |