The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia
Objective To verify possible associations between adenosine aminohydrolase (ADA) and AMP-aminohydrolase (AMPDA) to E3 SUMO-protein ligase NSE2 (NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group. Methods A total...
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| Format: | Article |
| Language: | English English |
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Elsevier
2015
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| Online Access: | http://irep.iium.edu.my/44462/ http://irep.iium.edu.my/44462/1/P_62.pdf http://irep.iium.edu.my/44462/4/44462_The%20effect%20of%20renal%20stones%20on%20serum%20adenosine%20aminohydrolase%20and%20AMP-aminohydrolase%20in%20Malaysia_SCOPUS.pdf |
| _version_ | 1848782611246219264 |
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| author | Yusof, Faridah Mehde, Atheer Awad Ghazali, Hamid Abd Rahman, Azlina |
| author_facet | Yusof, Faridah Mehde, Atheer Awad Ghazali, Hamid Abd Rahman, Azlina |
| author_sort | Yusof, Faridah |
| building | IIUM Repository |
| collection | Online Access |
| description | Objective
To verify possible associations between adenosine aminohydrolase (ADA) and AMP-aminohydrolase (AMPDA) to E3 SUMO-protein ligase NSE2 (NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group.
Methods
A total of 60 renal stones patients and 50 control were enrolled in a case–control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ELISA.
Results
Serum ADA, AMPDA and specific activity of enzymes showed significant decrease (P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a significant increase (P < 0.01 and P < 0.05, respectively) in patients compared to control group.
Conclusions
The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inflammation disorders in the patients with kidney stones. |
| first_indexed | 2025-11-14T16:08:12Z |
| format | Article |
| id | iium-44462 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:08:12Z |
| publishDate | 2015 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-444622017-11-17T07:44:03Z http://irep.iium.edu.my/44462/ The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia Yusof, Faridah Mehde, Atheer Awad Ghazali, Hamid Abd Rahman, Azlina R Medicine (General) Objective To verify possible associations between adenosine aminohydrolase (ADA) and AMP-aminohydrolase (AMPDA) to E3 SUMO-protein ligase NSE2 (NSMCE2) in patients with renal stones. And to isolate, purify and characterize ADA in patients with renal stones and healthy group. Methods A total of 60 renal stones patients and 50 control were enrolled in a case–control study. The blood urea, creatinine, uric acid, protein, albumin, ADA and AMPDA were measured by colorimetric tests. The serum NSMCE2 was measured by ELISA. Results Serum ADA, AMPDA and specific activity of enzymes showed significant decrease (P < 0.05) in patients with renal stones compared to control group, mean levels of sera NSMCE2 and uric acid had a significant increase (P < 0.01 and P < 0.05, respectively) in patients compared to control group. Conclusions The present study suggests that ADA, AMP deaminase and NSMCE2 can be used as a indicator to monitor the DNA damage and inflammation disorders in the patients with kidney stones. Elsevier 2015-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44462/1/P_62.pdf application/pdf en http://irep.iium.edu.my/44462/4/44462_The%20effect%20of%20renal%20stones%20on%20serum%20adenosine%20aminohydrolase%20and%20AMP-aminohydrolase%20in%20Malaysia_SCOPUS.pdf Yusof, Faridah and Mehde, Atheer Awad and Ghazali, Hamid and Abd Rahman, Azlina (2015) The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia. Asian Pacific Journal of Tropical Biomedicine, 5 (6). pp. 478-484. ISSN 2221 1691 http://www.sciencedirect.com/science/article/pii/S2221169115000738 10.1016/j.apjtb.2015.04.003 |
| spellingShingle | R Medicine (General) Yusof, Faridah Mehde, Atheer Awad Ghazali, Hamid Abd Rahman, Azlina The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title | The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title_full | The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title_fullStr | The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title_full_unstemmed | The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title_short | The effect of renal stones on serum adenosine aminohydrolase and AMP-aminohydrolase in Malaysia |
| title_sort | effect of renal stones on serum adenosine aminohydrolase and amp-aminohydrolase in malaysia |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/44462/ http://irep.iium.edu.my/44462/ http://irep.iium.edu.my/44462/ http://irep.iium.edu.my/44462/1/P_62.pdf http://irep.iium.edu.my/44462/4/44462_The%20effect%20of%20renal%20stones%20on%20serum%20adenosine%20aminohydrolase%20and%20AMP-aminohydrolase%20in%20Malaysia_SCOPUS.pdf |