Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes
S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS...
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| Format: | Article |
| Language: | English |
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Elsevier
2008
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| Online Access: | http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf |
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| author | How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. |
| author_facet | How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. |
| author_sort | How, Fiona Ni Foong |
| building | IIUM Repository |
| collection | Online Access |
| description | S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur
(OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated
complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative
bidentate ligand. The ligand and its metal complexes have been characterized by a variety of
physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione
form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the
S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.
SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)
while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective
activity towards targeted pathogens. |
| first_indexed | 2025-11-14T16:07:47Z |
| format | Article |
| id | iium-44289 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T16:07:47Z |
| publishDate | 2008 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-442892017-08-17T08:10:27Z http://irep.iium.edu.my/44289/ Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. QD Chemistry S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z' = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C=S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond. SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia) while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens. Elsevier 2008-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf How, Fiona Ni Foong and Crouse, Karen A. and M. Tahir, M. Ibrahim and Tarafder , M.T.H. and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes. Polyhedron, 27. pp. 3325-3329. ISSN 0277-5387 http://www.journals.elsevier.com/polyhedron/ |
| spellingShingle | QD Chemistry How, Fiona Ni Foong Crouse, Karen A. M. Tahir, M. Ibrahim Tarafder , M.T.H. Cowley, Andrew R. Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl) dithiocarbazate and its metal complexes |
| title | Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl)
dithiocarbazate and its metal complexes |
| title_full | Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl)
dithiocarbazate and its metal complexes |
| title_fullStr | Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl)
dithiocarbazate and its metal complexes |
| title_full_unstemmed | Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl)
dithiocarbazate and its metal complexes |
| title_short | Synthesis, characterization and biological studies of S-benzyl-b-N-(benzoyl)
dithiocarbazate and its metal complexes |
| title_sort | synthesis, characterization and biological studies of s-benzyl-b-n-(benzoyl)
dithiocarbazate and its metal complexes |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/ http://irep.iium.edu.my/44289/1/Polyhedron_27_%282008%29_3325%E2%80%933329.pdf |