Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children
Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
2011
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| Online Access: | http://irep.iium.edu.my/4276/ http://irep.iium.edu.my/4276/1/ADHD.pdf |
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| author | Kukreja, Ruchi Saxena, Anil Kumar Gurtu, Sunil Ali, Bashir Sitholey, Prabhat |
| author_facet | Kukreja, Ruchi Saxena, Anil Kumar Gurtu, Sunil Ali, Bashir Sitholey, Prabhat |
| author_sort | Kukreja, Ruchi |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition
in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive,
inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity
(AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole
and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was
investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities
in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA
is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only
in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen
only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated
with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this
condition. |
| first_indexed | 2025-11-14T14:27:58Z |
| format | Article |
| id | iium-4276 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:27:58Z |
| publishDate | 2011 |
| publisher | Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-42762012-01-04T06:47:57Z http://irep.iium.edu.my/4276/ Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children Kukreja, Ruchi Saxena, Anil Kumar Gurtu, Sunil Ali, Bashir Sitholey, Prabhat RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ101 Child Heatlh. Child health services. Preventive health services for children Introduction: Attention deficit hyperactivity disorder (ADHD) is a frequently encountered clinical condition in children. Based on DSM IV-TR criteria it can be sub-classified into three distinct types namely hyperactiveimpulsive, inattentive and combined. Materials and Methods: In the present study, salivary antioxidant activity (AOA) in children with ADHD was compared with age-matched normal control subjects, both as a whole and also with regard to the three subtypes. Additionally, the effect of therapy on the altered AOA levels was investigated following short term (<3 months) and long term (1–3 years) treatments. AOA and catalase activities in the saliva were estimated employing previously reported biochemical procedures. Results: While AOA is decreased in ADHD patients as compared to normal subjects, statistically significant decrease is seen only in the combined and the hyperactive-impulsive subtypes. Restoration of AOA and catalase activities is seen only after sustained therapy and not in the short term. Conclusion: It is concluded that ADHD is associated with decrease in AOA and this should possibly also be addressed for limiting the long term outcomes of this condition. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2011-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/4276/1/ADHD.pdf Kukreja, Ruchi and Saxena, Anil Kumar and Gurtu, Sunil and Ali, Bashir and Sitholey, Prabhat (2011) Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children. The International Medical Journal Malaysia, 10 (1). pp. 31-35. ISSN 1823-4631 http://www.e-imj.com/ |
| spellingShingle | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ101 Child Heatlh. Child health services. Preventive health services for children Kukreja, Ruchi Saxena, Anil Kumar Gurtu, Sunil Ali, Bashir Sitholey, Prabhat Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title | Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title_full | Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title_fullStr | Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title_full_unstemmed | Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title_short | Antioxidant activity in children with ADHD – a comparison in untreated and treated subjects with normal children |
| title_sort | antioxidant activity in children with adhd – a comparison in untreated and treated subjects with normal children |
| topic | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ101 Child Heatlh. Child health services. Preventive health services for children |
| url | http://irep.iium.edu.my/4276/ http://irep.iium.edu.my/4276/ http://irep.iium.edu.my/4276/1/ADHD.pdf |