Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

QR Code

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients

Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subje...

Full description

Bibliographic Details
Main Authors:	Zakaria, Bannur, Mohd Zaki, Salleh, Hashim, Hazwanie, Tom, Hennessy, Md Nor, Azmi, MH, Zailani, Prabu, Ramasamy, ZA, Zakaria, Suneet, S, Ngow, Harris Abdullah, Henry, Guy M., Teh, Laykek
Format:	Article
Language:	English English
Published:	International Journal of Pharmacy and Pharmaceutical Sciences ( IJPPS) 2014
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/42698/ http://irep.iium.edu.my/42698/1/metabolomics_and_pharmacogenetics_based_5-fluorouracil_monitoring_in_colorectal_cancer_patients.pdf http://irep.iium.edu.my/42698/4/42698_METABOLOMICS_scopus.pdf

Similar Items

Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
by: Bannur, Zakaria, et al.
Published: (2014)

Potential of dihydropyrimidine dehydrogenase genotypes in personalising 5-fluorouracil therapy among colorectal cancer patients
by: Ngow, Harris Abdullah, et al.
Published: (2011)

Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients
by: Teh, Lay Kek, et al.
Published: (2013)

Integrating pharmacogenomics- metabolomics towards realising personalised medicine for colorectal cancer patients treated with 5-fluorouracil / Hazwanie Hashim
by: Hashim, Hazwanie
Published: (2012)

5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
by: Yusefi, Mostafa, et al.
Published: (2021)

Pipeline pharmacogenetics: A novel approach to integrating pharmacogenetics into drug development
by: Akkari, Patrick, et al.
Published: (2009)

Variability in responses of tacrolimus in kidney transplant patients: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practices / Sharina Hamzah
by: Hamzah, Sharina
Published: (2013)

Pharmacogenetics, pharmacogenomics and airway disease
by: Hall, Ian P.
Published: (2002)

Notch-induced transcription factors are predictive of survival and 5-fluorouracil response in colorectal cancer patients
by: Candy, P., et al.
Published: (2013)

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia
by: Ware, James S., et al.
Published: (2017)

Interpatient variability in tamoxifen respone among breast cancer patient: the use of pharmacogenetics and metabolomics in closing the gaps in clinical practice / Nor Izwani Mohamed
by: Mohamed, Nor Izwani
Published: (2017)

Pharmacogenetics in cardiovascular disorders: An update on the principal drugs
by: Predazzi, I., et al.
Published: (2013)

Pharmacogenetics of beta adrenergic blockers: their clinical significance
by: Elsayed, Tarek Mohamed Ali
Published: (2009)

5-Fluorouracil encapsulated chitosan-cellulose fiber bionanocomposites: Synthesis, characterization and in vitro analysis towards colorectal cancer cells
by: Yusefi, Mostafa, et al.
Published: (2021)

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil-based chemotherapy
by: Collura, A., et al.
Published: (2014)

5-Fluorouracil induce the expression of TLR4 on HCT116 colorectal cancer cell line expressing different variants of TLR4
by: Davoodi, Homa, et al.
Published: (2013)

The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics
by: Amin, Arwa M., et al.
Published: (2017)

Green synthesis of Fe3O4 nanoparticles for hyperthermia, magnetic resonance imaging and 5-fluorouracil carrier in potential colorectal cancer treatment
by: Yusefi, Mostafa, et al.
Published: (2021)

The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach
by: Bannur, Zakaria, et al.
Published: (2014)

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
by: Soong, R., et al.
Published: (2008)

The role of pharmacogenetic variation in metoprolol CYP2D6 genotypes polymorphism
by: Wan Sulaiman, Wan Mohd. Azizi, et al.
Published: (2011)

Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies
by: Loh, M., et al.
Published: (2013)

Chitosan-Nanoparticles As A Drug Delivery System For 5-Fluorouracil
by: Suardi, Muslim
Published: (2003)

Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review
by: Roberts, B., et al.
Published: (2023)

A Clinical And Pharmacogenetic Investigation Of Methadone Maintenance Therapy (MMT) In Opiate Dependent Individuals
by: Mohamad, Nasir
Published: (2011)

Oxidative stress in primary open angle glaucoma: relevance of genetic polymorphisms of antioxidant genes and differential metabolite profiles / Zakaria Mohamed Bannur
by: Mohamed Bannur, Zakaria
Published: (2014)

A pharmacogenetics study on acute pain perception among patents on methadone maintenance therapy (MMT)
by: Zahari, Zalina
Published: (2016)

Cancerpharmacogenomics: the relevance of genetic profile in optimization drug therapy for azathiopurine and 5-Fluorouracil / Teh Lay Kek And Mohd Zaki Salleh
by: Teh, Lay Kek, et al.
Published: (2010)

Physical pegylation enhances the cytotoxicity of 5-fluorouracil-loaded PLGA And PCL nanoparticles.
by: Ashour, Abdelkader Elbadawy Abbas, et al.
Published: (2019)

Genetic polymorphism of drug metabolizing enzymes and estrogen receptor in pharmacogenetics of tamoxifen: implication for optimization of breast cancer treatment / Teh Lay Kek and Mohd Zaki Salleh
by: Lay Kek, Teh, et al.
Published: (2010)

Knowledge, perception and confidence of physicians and pharmacists at IIUM Medical Centre towards pharmacogenetics application in clinical setting
by: Azmi, Diyana, et al.
Published: (2019)

Benchmarking in silico tools for the functional assessment of DNA variants using a set of strictly pharmacogenetic variants
by: Chua, Eng Wee, et al.
Published: (2019)

Gold nanoparticles conjugated with anti-CD133 monoclonal antibody and 5-fluorouracil chemotherapeutic agent as nanocarriers for cancer cell targeting
by: Mohd-Zahid, Manali Haniti, et al.
Published: (2021)

Mitochondrial DNA quantity changes in leucocytes of cancer patients on cisplatin and 5-fluorouracil regimen
by: Khaing, Ei Phyo, et al.
Published: (2016)

The Thermal Stability of Lattice-Energy Minima of 5-Fluorouracil: Metadynamics as an Aid to Polymorph Prediction
by: Karamertzanis, P., et al.
Published: (2008)

The Personalization of Clopidogrel Antiplatelet Therapy in Coronary Artery Disease Patients using Pharmacometabonomics, Pharmacogenetics and Platelets Function Testing
by: Mostafa, Arwa Mohamed Amin
Published: (2016)

Imatinab mesylate treatment in Chronic Myeloid Leukemia (CML)- understanding the fundamental pharmacokinetic and pharmacogenetic mechanisms for variation in response
by: Ankathil, Ravindran
Published: (2016)

The potential anticancer activity of 5-fluorouracil loaded in cellulose fibers isolated from rice straw
by: Yusefi, Mostafa, et al.
Published: (2020)

Diagnostic yield of colonoscopy in patients with colorectal symptoms from two hospitals in Malaysia
by: Ramasamy, Prabhu, et al.
Published: (2010)

Colorectal carcinoma in Hospital Kuala Terengganu from 1987 to 1999
by: Ramasamy, Umasangar
Published: (2002)