An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE)

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An S188V mutation alters substrate specificity of non-stereospecific α-haloalkanoic acid dehalogenase E (DehE)

The non-stereospecific α-haloalkanoic acid dehalogenase E (DehE) degrades many halo- genated compounds but is ineffective against β-halogenated compounds such as 3- chloropropionic acid (3CP). Using molecular dynamics (MD) simulations and site-directed mutagenesis we show here that introducing th...

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Bibliographic Details
Main Authors:	Abdul Hamid, Azzmer Azzar, Tengku Abdul Hamid, Tengku Haziyamin, Abdul Wahab, Roswanira, Shamsir, Mohd Shahir, Huyop, Fahrul Zaman
Format:	Article
Language:	English
Published:	The Public Library of Science (PLoS) 2015
Subjects:	QR Microbiology TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/42599/ http://irep.iium.edu.my/42599/1/42599.pdf

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