Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antiox...
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| Format: | Proceeding Paper |
| Language: | English English |
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2015
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| Online Access: | http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf |
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| author | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher |
| author_facet | Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher |
| author_sort | Aminudin, Nurul Iman |
| building | IIUM Repository |
| collection | Online Access |
| description | Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antioxidant, cholinesterase and tyrosinase enzymatic inhibition activities of leaves and heartwood of Calophyllum symingtonianum, and the bark of Calophyllum depressinervosum were conducted. All extracts were tested for their total phenolic content and
antioxidant activities by DPPH radical scavenging and β-carotene bleaching. Cholinesterase inhibition by Ellman’s method and tyrosinase inhibition using L-DOPA as a substrate were also tested. All methanol extracts were found to exhibit strong DPPH radical scavenging effects. The
methanol extract of C. depressinervosum bark showed 95.08% inhibition of β-carotene bleaching and 78.46% inhibition against butyrylcholinesterase (BChE). All extracts showed moderate inhibition towards tyrosinase activity with an IC50 of more than 100 μg/mL. |
| first_indexed | 2025-11-14T16:03:00Z |
| format | Proceeding Paper |
| id | iium-42497 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:03:00Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-424972015-05-07T06:55:14Z http://irep.iium.edu.my/42497/ Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher RS Pharmacy and materia medica Calophyllum is a pan-tropical genus belongs to the Guttiferae family and locally known in Malaysia as “bintangor”. There has been a continual interest to further investigate the phytochemistry of Calophyllum spp since this genus is a rich source of active secondary metabolites. In this study, antioxidant, cholinesterase and tyrosinase enzymatic inhibition activities of leaves and heartwood of Calophyllum symingtonianum, and the bark of Calophyllum depressinervosum were conducted. All extracts were tested for their total phenolic content and antioxidant activities by DPPH radical scavenging and β-carotene bleaching. Cholinesterase inhibition by Ellman’s method and tyrosinase inhibition using L-DOPA as a substrate were also tested. All methanol extracts were found to exhibit strong DPPH radical scavenging effects. The methanol extract of C. depressinervosum bark showed 95.08% inhibition of β-carotene bleaching and 78.46% inhibition against butyrylcholinesterase (BChE). All extracts showed moderate inhibition towards tyrosinase activity with an IC50 of more than 100 μg/mL. 2015-03 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf application/pdf en http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher (2015) Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum. In: International Conference on Natural Products 2015, 24-25 March 2015, Double Tree by Hilton, Johor Bahru. (Unpublished) http://science.utm.my/icnp2015/ |
| spellingShingle | RS Pharmacy and materia medica Aminudin, Nurul Iman Ahmad, Farediah Bakhtiar, M. Taher Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum |
| title | Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
|
| title_full | Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
|
| title_fullStr | Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
|
| title_full_unstemmed | Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
|
| title_short | Antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum
|
| title_sort | antioxidant, cholinesterase and tyrosinase inhibitory activities of calophyllum symingtonianum and calophyllum depressinervosum |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/ http://irep.iium.edu.my/42497/1/ICNP_2015_abstract_Iman.pdf http://irep.iium.edu.my/42497/2/POSTER_ICNP_2015_NURUL_IMAN.pdf |