Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging...
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| Format: | Proceeding Paper |
| Language: | English English |
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2014
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| Online Access: | http://irep.iium.edu.my/42170/ http://irep.iium.edu.my/42170/11/42170-certificate.pdf http://irep.iium.edu.my/42170/13/42170_poster.pdf |
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| author | Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko |
| author_facet | Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko |
| author_sort | Lestari, Widya |
| building | IIUM Repository |
| collection | Online Access |
| description | Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases.
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| first_indexed | 2025-11-14T16:02:09Z |
| format | Proceeding Paper |
| id | iium-42170 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:02:09Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-421702021-06-08T16:19:50Z http://irep.iium.edu.my/42170/ Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko RK Dentistry Dietary antioxidants are substances in foods that significantly decrease the adverse effects of reactive oxygen species, reactive nitrogen species, or both on normal physiological function in humans. Mostly found in fruits and vegetables, they prevent free radicals from attacking cells and damaging DNA. Epidemiological evidences have suggested that intake of fruits and vegetables reduces the risk of both cancer and cardiovascular disease. Flavonoids, carotenoids, vitamin C, vitamin E and selenium are the major dietary antioxidants. Several large intervention studies have thus been conducted with beta-carotene and vitamin E, leading investigations on chemoprevention of chronic diseases with dietary antioxidants. However, beta-carotene supplementation has shown not only positive but also negative effects on human health. The antioxidant activity of these compounds may shift into prooxidant activity, depending on the redox potential of the carotenoid molecules as well as on the biological environment in which they act. The prooxidant potency of these compounds is determined by several factors, including oxygen tension, carotenoid concentration, and interactions with other antioxidants. Prooxidant activity can induce harmful results in biologic systems and influence the development of human chronic diseases. 2014 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/42170/11/42170-certificate.pdf application/pdf en http://irep.iium.edu.my/42170/13/42170_poster.pdf Lestari, Widya and Jaswir, Irwandi and Nordin, Nur Sazwi and Octavianti, Fitri and Nagao, Akihiko (2014) Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Kuala Lumpur. (Unpublished) |
| spellingShingle | RK Dentistry Lestari, Widya Jaswir, Irwandi Nordin, Nur Sazwi Octavianti, Fitri Nagao, Akihiko Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases |
| title | Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
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| title_full | Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
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| title_fullStr | Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
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| title_full_unstemmed | Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
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| title_short | Dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases
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| title_sort | dose-dependence of dietary antioxidants in their biological actions for research in human chronic diseases |
| topic | RK Dentistry |
| url | http://irep.iium.edu.my/42170/ http://irep.iium.edu.my/42170/11/42170-certificate.pdf http://irep.iium.edu.my/42170/13/42170_poster.pdf |