In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line
Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate. Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of ex...
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2014
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| Online Access: | http://irep.iium.edu.my/41532/ http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf |
| _version_ | 1848782138355220480 |
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| author | Ibrahim, Wisam Nabeel Abdull Rasad, Mohammad Syaiful Bahari Abdul Wahab, Ridhwan Hashim, Ridzwan |
| author_facet | Ibrahim, Wisam Nabeel Abdull Rasad, Mohammad Syaiful Bahari Abdul Wahab, Ridhwan Hashim, Ridzwan |
| author_sort | Ibrahim, Wisam Nabeel |
| building | IIUM Repository |
| collection | Online Access |
| description | Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate.
Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of extra cellular matrix components and their role in tumor invasion and metastasis has been proven through many studies in many types of cancers. Many MMPs including all collagenases contain AP-1 DNA binding sites in their gene promoters, and they are transcriptionally regulated via this site.
CTCF & Yb-1 transcription factors are among the many proteins which can bind specifically to AP-1 site of MMPs promoter gene.
This study aimed to detect the interaction between CTCF or YB-1 transcription factors with the AP-1 site of MMP-13 gene promoter. This approach was performed to discover a probable therapeutic pathway through the effect of this protein – DNA interaction on the expression of MMP-13 which is a key factor in the process of malignant melanoma skin cancer invasion |
| first_indexed | 2025-11-14T16:00:41Z |
| format | Proceeding Paper |
| id | iium-41532 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T16:00:41Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-415322022-07-15T07:48:32Z http://irep.iium.edu.my/41532/ In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line Ibrahim, Wisam Nabeel Abdull Rasad, Mohammad Syaiful Bahari Abdul Wahab, Ridhwan Hashim, Ridzwan QP Physiology Skin cancer is one of the most common malignancies in young adults. Among all types of skin cancers, malignant melanoma is the most serious tumor in terms of local invasiveness and mortality rate. Matrix metalloproteinase (MMP) family of enzymes are key enzymes responsible for the degradation of extra cellular matrix components and their role in tumor invasion and metastasis has been proven through many studies in many types of cancers. Many MMPs including all collagenases contain AP-1 DNA binding sites in their gene promoters, and they are transcriptionally regulated via this site. CTCF & Yb-1 transcription factors are among the many proteins which can bind specifically to AP-1 site of MMPs promoter gene. This study aimed to detect the interaction between CTCF or YB-1 transcription factors with the AP-1 site of MMP-13 gene promoter. This approach was performed to discover a probable therapeutic pathway through the effect of this protein – DNA interaction on the expression of MMP-13 which is a key factor in the process of malignant melanoma skin cancer invasion 2014-12 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf application/pdf en http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf Ibrahim, Wisam Nabeel and Abdull Rasad, Mohammad Syaiful Bahari and Abdul Wahab, Ridhwan and Hashim, Ridzwan (2014) In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line. In: International Health Conference IIUM 2014, 3rd-4th December 2014, Kuantan, Pahang. (Unpublished) |
| spellingShingle | QP Physiology Ibrahim, Wisam Nabeel Abdull Rasad, Mohammad Syaiful Bahari Abdul Wahab, Ridhwan Hashim, Ridzwan In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title | In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title_full | In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title_fullStr | In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title_full_unstemmed | In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title_short | In vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| title_sort | in vivo ctcf and yb-1 interaction with ap-1 site of matrix metalloproteinase 13 gene promoter in human malignant melanoma cell line |
| topic | QP Physiology |
| url | http://irep.iium.edu.my/41532/ http://irep.iium.edu.my/41532/2/Poster_Template_vivo.pdf http://irep.iium.edu.my/41532/3/IHCI_2014_Programme_Book.pdf |