Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

QR Code

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells

To investigate whether dysregulation of p53 phosphorylation confers tumor resistance to p53, we analysed the effects of wild-type p53 on oral squamous cell carcinoma(SCC) cell lines carrying various mutations of p53. Introduction of exogenous p53 neither induced apoptosis nor suppressed colony form...

Full description

Bibliographic Details
Main Authors:	Arief Ichwan, Solachuddin Jauhari, Shumpei, Yamada, Piyamas, Sumrejkanchanakij, Elza, Ibrahim-Auerkari, K, Eto, Ikeda, Masa-Aki
Format:	Article
Language:	English
Published:	Nature 2006
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/4137/ http://irep.iium.edu.my/4137/1/1209158a.pdf

Similar Items

Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation
by: Teng, Ma, et al.
Published: (2012)

Defect in ser46 phosphorylation of p53 protein: a resistance mechanism against p53 gene transfer in oral squamos cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2008)

Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2011)

Therapeutic targeting of p53-mediated apoptosis pathway in head and neck squamous cell carcinomas: current progress and challenges
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2012)

Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage
by: Lestari, Widya, et al.
Published: (2012)

Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis
by: Pratama, Endrawan, et al.
Published: (2015)

Utility of Ki-67 and p53 in distinguishing cervical intraepithelial neoplasia 3 from squamous cell carcinoma of the cervix
by: Tan, Geok Chin, et al.
Published: (2008)

Cofactor strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
by: Maniam, Sandra, et al.
Published: (2015)

Redox regulation of p53, redox effectors regulated by p53: A subtle balance
by: Maillet, A., et al.
Published: (2012)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

Growth Suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73beta
by: Hayati, Rahma Fitri, et al.
Published: (2010)

Growth suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73B
by: Hayati, Rahma Fitri, et al.
Published: (2010)

Crosstalk between p53 and mitochondrial metabolism
by: Itahana, K., et al.
Published: (2014)

Involvement of the P53 pathway and P161NK4A in the pathogenesis of b-cell lymphomas
by: Zainuddin, Norafiza
Published: (2011)

Analysis of the anti-cancer effect of ethyl-p-methoxycinnamate extracted cekur (Kaempferia galanga) on cancer cell lines with wild-type and null p53
by: Ichwan, Solachuddin J. A., et al.
Published: (2020)

Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
by: Zakaria, Yusmazura, et al.
Published: (2009)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
by: Ismail, Norzila, et al.
Published: (2005)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
by: Ismail, Norzila, et al.
Published: (2005)

Synergistic anti-cancer effects of recombinant adenoviruses DRIL1 and p53 gene transfer against human lung cancer cells
by: Arief Ichwan, Solachuddin Jauhari
Published: (2011)

Molecular genetic analysis in B-cell Lymphomas : a focus on the p53 pathway and p16INK4a
by: Zainuddin, Norafiza
Published: (2010)

Construction of the pEGFP-N1-p53/MAR vector and its effect on HEP3B cell morphology
by: Li, Peng Shan, et al.
Published: (2018)

The inter-relationship between p53, survivin and XIAP in colorectal cancer cells response to apoptotic stimuli
by: Atakpa, Isaac
Published: (2024)

Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage
by: Lestari, Widya, et al.
Published: (2013)

In vitro anticancer potentials of ethyl p-methoxycinnamate (EPMC) an active ingredient of cekur (Kaempferia galanga) on human oral cancer cell lines differing in p53 status.
by: Ichwan, Solachuddin J. A., et al.
Published: (2018)

Production of recombinant p53 protein by PCR-based site directed mutagenesis of plasmid DNA
by: Bakhtiar, M. Taher, et al.
Published: (2010)

Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
by: Tan GC,, et al.
Published: (2007)

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
by: Amrank, Fitreena Anis
Published: (2016)

A preliminary study of p53 oncogene expression in lung samples
by: Rahman, Md.Tahminur
Published: (2003)

A gain of function p53 gene mutant promotes growth suppression in human liver cancer cells
by: Nor Adzimah Johdi,, et al.
Published: (2017)

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
by: Shafee, Norazizah, et al.
Published: (2008)

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells
by: Abdul Aziz, Muhammad Yusran, et al.
Published: (2014)

p53-Mdm2 interaction targeted therapy by Nutlin-3 on nasopharyngeal carcinoma cells / Voon Yee Lin
by: Voon, Yee Lin
Published: (2016)

Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis.
by: Ho, Wan Yong, et al.
Published: (2011)

Suppression Effect of Eurycomanone on the Growth of Human Hepatoma Cells (Hepg2) by Inducing P53-Mediated Apoptotic Pathway
by: Zakaria, Yusmazura
Published: (2009)

P53 and E7 expression status in human cervical carcinoma cell (HELA) treated with quercusinfectoria aqueous extract
by: Radzuan, Syazatul Aniza
Published: (2015)

Ranibizumab inhibits human tenon’s fibroblast proliferation via p21 dependent p53 mechanisms
by: Siti Munirah Md Noh,, et al.
Published: (2021)

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma.
by: Abdulamir, Ahmed Sahib, et al.
Published: (2008)

Small molecule inhibitors of the p53-MDM2 protein-protein interaction
by: Fitzgerald, Ross Patrick
Published: (2011)

Profiling post translational modification of histone and p53 in human breast carcinomas
by: Abdelghany, Magdy Korashy
Published: (2011)

Expression of p53 protein in premenopausal women as risk factors for breast cancer
by: Rashidah S,, et al.
Published: (2016)