Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum
Cellulose is the most abundant biopolymer on earth. Enzymatic degradation of this biopolymer is a crucial step toward its conversion to bioethanol. However the current cellulosic enzymes are unable to withstand high temperature of industrial processes. In this work we use computer simulations to pre...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/41304/ http://irep.iium.edu.my/41304/1/IIRIE_2014_EG_PosterID_485.pdf http://irep.iium.edu.my/41304/4/computational_prediction.pdf |
| _version_ | 1848782092740067328 |
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| author | Noorbatcha, Ibrahim Ali Ahmad, Abdul Aziz Mohd. Salleh, Hamzah |
| author_facet | Noorbatcha, Ibrahim Ali Ahmad, Abdul Aziz Mohd. Salleh, Hamzah |
| author_sort | Noorbatcha, Ibrahim Ali |
| building | IIUM Repository |
| collection | Online Access |
| description | Cellulose is the most abundant biopolymer on earth. Enzymatic degradation of this biopolymer is a crucial step toward its conversion to bioethanol. However the current cellulosic enzymes are unable to withstand high temperature of industrial processes. In this work we use computer simulations to predict thermostable endoglucanase. The molecular dynamics simulation is a powerful tool that can be used to study the enzymes behaviour at high temperature. On the basis of computer simulations we have predicted a mutant endoglucanase with improved thermal stability properties. |
| first_indexed | 2025-11-14T15:59:58Z |
| format | Proceeding Paper |
| id | iium-41304 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:59:58Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-413042021-06-30T08:09:55Z http://irep.iium.edu.my/41304/ Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum Noorbatcha, Ibrahim Ali Ahmad, Abdul Aziz Mohd. Salleh, Hamzah TP Chemical technology TP248.13 Biotechnology Cellulose is the most abundant biopolymer on earth. Enzymatic degradation of this biopolymer is a crucial step toward its conversion to bioethanol. However the current cellulosic enzymes are unable to withstand high temperature of industrial processes. In this work we use computer simulations to predict thermostable endoglucanase. The molecular dynamics simulation is a powerful tool that can be used to study the enzymes behaviour at high temperature. On the basis of computer simulations we have predicted a mutant endoglucanase with improved thermal stability properties. 2014-06-11 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/41304/1/IIRIE_2014_EG_PosterID_485.pdf application/pdf en http://irep.iium.edu.my/41304/4/computational_prediction.pdf Noorbatcha, Ibrahim Ali and Ahmad, Abdul Aziz and Mohd. Salleh, Hamzah (2014) Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Cultural Activity Center (CAC), Internatioanal Islamic University Malaysia. (Unpublished) http://www.iium.edu.my/irie/14/ |
| spellingShingle | TP Chemical technology TP248.13 Biotechnology Noorbatcha, Ibrahim Ali Ahmad, Abdul Aziz Mohd. Salleh, Hamzah Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title | Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title_full | Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title_fullStr | Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title_full_unstemmed | Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title_short | Computational prediction and development of a thermostable endoglucanase I from Fusarium oxysporum |
| title_sort | computational prediction and development of a thermostable endoglucanase i from fusarium oxysporum |
| topic | TP Chemical technology TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/41304/ http://irep.iium.edu.my/41304/ http://irep.iium.edu.my/41304/1/IIRIE_2014_EG_PosterID_485.pdf http://irep.iium.edu.my/41304/4/computational_prediction.pdf |