Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine
A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data o...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/41262/ http://irep.iium.edu.my/41262/1/icnp2014.pdf http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf |
| _version_ | 1848782085253234688 |
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| author | Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti |
| author_facet | Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti |
| author_sort | Mohamed, Nor Azanita |
| building | IIUM Repository |
| collection | Online Access |
| description | A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data of the compounds were in agreement with the calculated values. The FTIR spectra showed the presence of important bands of the compounds and 1H and 13C exhibited expected chemical shift. Antibacterial and anti fungal activities have been evaluated by zone of inhibition, MIC and MBC/MFC studies against B.cereus, S.epidermidis, E. coli, P.aeruginosa, C. Albicans and T. metagrophytes. Most of the compounds showed moderate antibacterial activity against B.cereus and S.epidermidis and moderate to excellent anti fungal activity against T.metagrophytes. The antimicrobial activities of the compounds were related to the different position of fluoro atom substitution and a-and b-alanine presence in the compounds |
| first_indexed | 2025-11-14T15:59:51Z |
| format | Proceeding Paper |
| id | iium-41262 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:59:51Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-412622018-06-19T08:33:43Z http://irep.iium.edu.my/41262/ Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti QD Chemistry A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data of the compounds were in agreement with the calculated values. The FTIR spectra showed the presence of important bands of the compounds and 1H and 13C exhibited expected chemical shift. Antibacterial and anti fungal activities have been evaluated by zone of inhibition, MIC and MBC/MFC studies against B.cereus, S.epidermidis, E. coli, P.aeruginosa, C. Albicans and T. metagrophytes. Most of the compounds showed moderate antibacterial activity against B.cereus and S.epidermidis and moderate to excellent anti fungal activity against T.metagrophytes. The antimicrobial activities of the compounds were related to the different position of fluoro atom substitution and a-and b-alanine presence in the compounds 2014-03-18 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/41262/1/icnp2014.pdf application/pdf en http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf Mohamed, Nor Azanita and Ngah, Nurziana and Darnis, Deny Susanti (2014) Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine. In: International Conference on Natural Products 2014 (ICNP 2014), 18th-19th March 2014, Palm Garden Hotel, IOI Resorts, Putrajaya, Malaysia. (Unpublished) |
| spellingShingle | QD Chemistry Mohamed, Nor Azanita Ngah, Nurziana Darnis, Deny Susanti Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title | Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title_full | Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title_fullStr | Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title_full_unstemmed | Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title_short | Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| title_sort | synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/41262/ http://irep.iium.edu.my/41262/1/icnp2014.pdf http://irep.iium.edu.my/41262/3/ICNP2014_nurziana.pdf |