Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development
The recent surge in multidrug-resistant pathogens combined with the diminishing antibiotic pipeline has created a growing need to optimize the use of our existing antibiotic armamentarium, particularly in the management of intensive care unit (ICU) patients. Optimal and timely pharmacokinetic/pha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/41237/ http://irep.iium.edu.my/41237/1/s-0034-1398490.pdf |
| _version_ | 1848782080148766720 |
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| author | Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Mouton, Johan W. Hope, William W. Roberts, Jason A. |
| author_facet | Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Mouton, Johan W. Hope, William W. Roberts, Jason A. |
| author_sort | Abdul Aziz, Mohd. Hafiz |
| building | IIUM Repository |
| collection | Online Access |
| description | The recent surge in multidrug-resistant pathogens combined with the diminishing
antibiotic pipeline has created a growing need to optimize the use of our existing
antibiotic armamentarium, particularly in the management of intensive care unit (ICU)
patients. Optimal and timely pharmacokinetic/pharmacodynamic (PK/PD) target attainment
has been associated with an increased likelihood of clinical andmicrobiological
success in critically ill patients. Emerging data, mostly from in vitro and in vivo studies,
suggest that optimization of antibiotic therapy should not only aim to maximize clinical
outcomes but also to include the suppression of resistance. The development of
antibiotic dosing regimens that adheres to the PK/PD principles may prolong the
clinical lifespan of our existing antibiotics by minimizing the emergence of resistance.
This article summarizes the relevance of PK/PD characteristics of different antibiotic
classes on the development of antibiotic resistance. On the basis of the available data,
we propose dosing recommendations that can be adopted in the clinical setting, to
maximize therapeutic success and limit the emergence of resistance in the ICU. |
| first_indexed | 2025-11-14T15:59:46Z |
| format | Article |
| id | iium-41237 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:59:46Z |
| publishDate | 2015 |
| publisher | Thieme Medical Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-412372016-11-11T08:29:46Z http://irep.iium.edu.my/41237/ Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Mouton, Johan W. Hope, William W. Roberts, Jason A. RM Therapeutics. Pharmacology RS Pharmacy and materia medica The recent surge in multidrug-resistant pathogens combined with the diminishing antibiotic pipeline has created a growing need to optimize the use of our existing antibiotic armamentarium, particularly in the management of intensive care unit (ICU) patients. Optimal and timely pharmacokinetic/pharmacodynamic (PK/PD) target attainment has been associated with an increased likelihood of clinical andmicrobiological success in critically ill patients. Emerging data, mostly from in vitro and in vivo studies, suggest that optimization of antibiotic therapy should not only aim to maximize clinical outcomes but also to include the suppression of resistance. The development of antibiotic dosing regimens that adheres to the PK/PD principles may prolong the clinical lifespan of our existing antibiotics by minimizing the emergence of resistance. This article summarizes the relevance of PK/PD characteristics of different antibiotic classes on the development of antibiotic resistance. On the basis of the available data, we propose dosing recommendations that can be adopted in the clinical setting, to maximize therapeutic success and limit the emergence of resistance in the ICU. Thieme Medical Publishers 2015-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/41237/1/s-0034-1398490.pdf Abdul Aziz, Mohd. Hafiz and Lipman, Jeffrey and Mouton, Johan W. and Hope, William W. and Roberts, Jason A. (2015) Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development. Seminars in Respiratory and Critical Care Medicine, 36 (1). pp. 136-153. ISSN 1069-3424. http://www.thieme.com/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=915&category_id=90&option=com_virtuemart&Itemid=53 http://dx.doi.org/ 10.1055/s-0034-1398490 |
| spellingShingle | RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul Aziz, Mohd. Hafiz Lipman, Jeffrey Mouton, Johan W. Hope, William W. Roberts, Jason A. Applying pharmacokinetic/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development |
| title | Applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| title_full | Applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| title_fullStr | Applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| title_full_unstemmed | Applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| title_short | Applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| title_sort | applying pharmacokinetic/pharmacodynamic
principles in critically ill patients: optimizing
efficacy and reducing resistance development |
| topic | RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/41237/ http://irep.iium.edu.my/41237/ http://irep.iium.edu.my/41237/ http://irep.iium.edu.my/41237/1/s-0034-1398490.pdf |