Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats
Introduction: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ) -induced diabetes mellitus in rats. Methods: The effects of an aqueous extract of A. squamosa leaves on blood glucose, i...
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| Format: | Article |
| Language: | English |
| Published: |
Singapore Medical Association
2008
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/40987/ http://irep.iium.edu.my/40987/1/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf |
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| author | Kaleem, Mohammed Medha, P. Ahmed, Qamar Uddin Asif, Mohd S. Bano, Bilqees |
| author_facet | Kaleem, Mohammed Medha, P. Ahmed, Qamar Uddin Asif, Mohd S. Bano, Bilqees |
| author_sort | Kaleem, Mohammed |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: The present study investigated the
possible therapeutic effects of Annona squamosa
(A. squamosa) extract on certain biochemical
markers in streptozotocin (STZ) -induced
diabetes mellitus in rats.
Methods: The effects of an aqueous extract of
A. squamosa leaves on blood glucose, insulin,
C-peptide, albumin, albumin/globulin ratio,
urea, uric acid and creatinine and the activities
of diagnostic marker enzymes aspartate
aminotransferase, alanine aminotransferase,
alkaline phosphatase and gamma-glutamyl
transpeptidase were examined in the plasma, liver
and kidney tissues of control and experimental
groups.
Results: Oral administration of A. squamosa (300
mg/kg) aqueous extract to diabetic rats for 30 days
significantly reduced blood glucose, urea, uric
acid and creatinine, but increased the activities
of insulin, C-peptide, albumin, albumin/globulin
ratio and restored all marker enzymes to near
control levels.
Conclusion: The present results shown that A.
squamosa extract has an antihyperglycaemic
effect and consequently may alleviate liver and
renal damage associated with STZ-induced
diabetes mellitus in rats.
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| first_indexed | 2025-11-14T15:59:05Z |
| format | Article |
| id | iium-40987 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:59:05Z |
| publishDate | 2008 |
| publisher | Singapore Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-409872015-03-10T00:48:08Z http://irep.iium.edu.my/40987/ Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats Kaleem, Mohammed Medha, P. Ahmed, Qamar Uddin Asif, Mohd S. Bano, Bilqees Q Science (General) Introduction: The present study investigated the possible therapeutic effects of Annona squamosa (A. squamosa) extract on certain biochemical markers in streptozotocin (STZ) -induced diabetes mellitus in rats. Methods: The effects of an aqueous extract of A. squamosa leaves on blood glucose, insulin, C-peptide, albumin, albumin/globulin ratio, urea, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Results: Oral administration of A. squamosa (300 mg/kg) aqueous extract to diabetic rats for 30 days significantly reduced blood glucose, urea, uric acid and creatinine, but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. Conclusion: The present results shown that A. squamosa extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats. Singapore Medical Association 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40987/1/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf Kaleem, Mohammed and Medha, P. and Ahmed, Qamar Uddin and Asif, Mohd S. and Bano, Bilqees (2008) Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal, 49 (10). pp. 800-804. ISSN 0037-5675 http://smj.sma.org.sg/4910/4910a7.pdf |
| spellingShingle | Q Science (General) Kaleem, Mohammed Medha, P. Ahmed, Qamar Uddin Asif, Mohd S. Bano, Bilqees Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title | Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title_full | Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title_fullStr | Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title_short | Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats |
| title_sort | beneficial effects of annona squamosa extract in streptozotocin-induced diabetic rats |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/40987/ http://irep.iium.edu.my/40987/ http://irep.iium.edu.my/40987/1/Beneficial_effects_of_Annona_squamosa_extract_in_streptozotocin-induced_diabetic_rats..pdf |