Beyond anticoagulant: heparin as a potential anti-cancer agent
Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hibiscus Publisher
2014
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf |
| _version_ | 1848782018025881600 |
|---|---|
| author | Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari |
| author_facet | Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari |
| author_sort | Lokwani, Ravi |
| building | IIUM Repository |
| collection | Online Access |
| description | Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest the progression of tumors specially some solid forms of tumors such as small cell lung carcinoma and pancreatic tumors. The chemically modified and light molecular weight fractions of heparin have been found to be more active in countering tumor progression. In this review we discuss a brief history of this versatile biomolecule with its clinical data and postulated mechanism of action as per recent studies. This review also highlighted the approach of heparin-conjugated nanoparticles to achieve targeted drug delivery with synergistic response in tumor cells. |
| first_indexed | 2025-11-14T15:58:47Z |
| format | Article |
| id | iium-40862 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:58:47Z |
| publishDate | 2014 |
| publisher | Hibiscus Publisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-408622015-05-13T09:18:18Z http://irep.iium.edu.my/40862/ Beyond anticoagulant: heparin as a potential anti-cancer agent Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari RM300 Drugs and their action Heparin has been in the market since the last six decades due to its potential anticoagulant property. The mechanism of its anti-coagulation effect is well established. Along with its anticoagulant activity the other activity that is gathering a lot of importance now-a-days is its ability to arrest the progression of tumors specially some solid forms of tumors such as small cell lung carcinoma and pancreatic tumors. The chemically modified and light molecular weight fractions of heparin have been found to be more active in countering tumor progression. In this review we discuss a brief history of this versatile biomolecule with its clinical data and postulated mechanism of action as per recent studies. This review also highlighted the approach of heparin-conjugated nanoparticles to achieve targeted drug delivery with synergistic response in tumor cells. Hibiscus Publisher 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf Lokwani, Ravi and Azmi, Nina Suhaity and Mohd Yusoff, Mashitah and Arief Ichwan, Solachuddin Jauhari (2014) Beyond anticoagulant: heparin as a potential anti-cancer agent. Journal of Biochemistry, Microbiology and Biotechnology, 2 (2). pp. 37-43. ISSN 2289-5779 http://journal.hibiscuspublisher.com/index.php/JOBIMB/article/view/160 |
| spellingShingle | RM300 Drugs and their action Lokwani, Ravi Azmi, Nina Suhaity Mohd Yusoff, Mashitah Arief Ichwan, Solachuddin Jauhari Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title | Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title_full | Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title_fullStr | Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title_full_unstemmed | Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title_short | Beyond anticoagulant: heparin as a potential anti-cancer agent |
| title_sort | beyond anticoagulant: heparin as a potential anti-cancer agent |
| topic | RM300 Drugs and their action |
| url | http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/ http://irep.iium.edu.my/40862/1/JOBIMB.VOL_2_NO_2_MSCPT_7_37-44.pdf |