Isolation and anti-proliferative activity of natural products from green seaweed
Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplor...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/40506/ http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf |
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| author | Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher |
| author_facet | Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher |
| author_sort | Zulhedi Ilyas, Fitriyanti |
| building | IIUM Repository |
| collection | Online Access |
| description | Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplored yet. The aims of this study are to isolate phytochemical from selected Malaysian seaweed and to investigate the antiproliferative activity of isolated compounds. Seaweed is extracted by soxhlet extractor with using organic solvents for 24 hours, and then the crude seaweed is fractionated by vacuum liquid chromatography and column chromatography. The isolated compounds of seaweed are characterized by HRMS, FTIR spectroscopy, 1D and 2D NMR spectroscopy. They also are studied for their ability to inhibit cell proliferation of breast cancer cell MCF-7 using MTT assay. Two isolated compounds that were identified as Coumarin derivative showed activity against MCF-7. |
| first_indexed | 2025-11-14T15:58:00Z |
| format | Proceeding Paper |
| id | iium-40506 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:58:00Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-405062015-01-26T02:48:43Z http://irep.iium.edu.my/40506/ Isolation and anti-proliferative activity of natural products from green seaweed Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher QD Chemistry Seaweeds are marine organism that is chemically rich in source of different bioactive compounds of secondary metabolites. Selected green seaweed has been commonly consumed as human food due to their nutrient content. However, huge numbers of bioactive metabolites from green seaweed has been unexplored yet. The aims of this study are to isolate phytochemical from selected Malaysian seaweed and to investigate the antiproliferative activity of isolated compounds. Seaweed is extracted by soxhlet extractor with using organic solvents for 24 hours, and then the crude seaweed is fractionated by vacuum liquid chromatography and column chromatography. The isolated compounds of seaweed are characterized by HRMS, FTIR spectroscopy, 1D and 2D NMR spectroscopy. They also are studied for their ability to inhibit cell proliferation of breast cancer cell MCF-7 using MTT assay. Two isolated compounds that were identified as Coumarin derivative showed activity against MCF-7. 2014 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf application/pdf en http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf Zulhedi Ilyas, Fitriyanti and Darnis, Deny Susanti and Mohammad Noor, Normawaty and Bakhtiar, M. Taher (2014) Isolation and anti-proliferative activity of natural products from green seaweed. In: 5th International Conference on Science & Technology: Applications in Industry & Education (ICSTIE 2014), 17-18 September 2014, Parkroyal Resort, Penang. |
| spellingShingle | QD Chemistry Zulhedi Ilyas, Fitriyanti Darnis, Deny Susanti Mohammad Noor, Normawaty Bakhtiar, M. Taher Isolation and anti-proliferative activity of natural products from green seaweed |
| title | Isolation and anti-proliferative activity of natural products from green seaweed |
| title_full | Isolation and anti-proliferative activity of natural products from green seaweed |
| title_fullStr | Isolation and anti-proliferative activity of natural products from green seaweed |
| title_full_unstemmed | Isolation and anti-proliferative activity of natural products from green seaweed |
| title_short | Isolation and anti-proliferative activity of natural products from green seaweed |
| title_sort | isolation and anti-proliferative activity of natural products from green seaweed |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/40506/ http://irep.iium.edu.my/40506/1/ICSTIE2014.pdf http://irep.iium.edu.my/40506/6/Green_Seaweed_.pdf |