The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma.
Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Fi...
| Main Authors: | , , , , , , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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2014
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| Online Access: | http://irep.iium.edu.my/40378/ http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf |
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| author | Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher |
| author_facet | Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher |
| author_sort | Flanagan, John G |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls.
Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only
from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol.
Results: The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29mL/min; group mean control RBF = 40.68±11.32mL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the
POAG group (p=<0.01 for both superior & inferior RBF). The
average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no
correlation between the inferior RBF and RNFL thickness (r=0.30,p=0.09).
Conclusions: There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG. |
| first_indexed | 2025-11-14T15:57:36Z |
| format | Proceeding Paper |
| id | iium-40378 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:57:36Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-403782015-08-04T00:42:34Z http://irep.iium.edu.my/40378/ The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher RE Ophthalmology Purpose: To investigate the relationship between Doppler SD-OCT derived retinal blood flow (RBF) and the retinal nerve fiber layer (RNFL) thickness in patients with primary open angle glaucoma (POAG) and healthy age-matched controls. Methods: Thirty three POAG patients (age, 65±8 years; Humphrey Field Analyzer, HFA, mean deviation, MD, -2.28±3.85) and 33 healthy controls (age, 63±5 years; HFA MD -0.48±1.56) were recruited. The Doppler SD-OCT retinal blood flow measurement was taken using the circum-papillary double circular scan protocol in the RTVue system (Optovue Inc., Freemont, CA, USA). A minimum of six RBF scans were acquired. Flow parameters were calculated only from the valid scans. Peri-papillary RNFL thickness was measured using RTVue’s RNFL scan protocol. Results: The total RBF in the POAG group was significantly lower than in the control group (group mean POAG RBF = 30.61±9.29mL/min; group mean control RBF = 40.68±11.32mL/min; p=<0.01). Superior and inferior RBF were also significantly lower in the POAG group (p=<0.01 for both superior & inferior RBF). The average RNFL thickness, superior and inferior RNFL thickness were significantly lower in the POAG group (p=<0.01). Linear regression analysis showed a significant positive correlation between the total RBF and average RNFL thickness (r=0.38, p=0.03), and the superior RBF and superior RNFL thickness (r=0.37, p=0.01). There was no correlation between the inferior RBF and RNFL thickness (r=0.30,p=0.09). Conclusions: There was an association between thinning of the RNFL and reduced inner retinal perfusion in the eyes of patients with POAG. 2014 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf application/pdf en http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf Flanagan, John G and Yusof, Firdaus and Cheng, Richard and Tayyari, Faryan and Espahbodi, Nadia and Khuu, Lee-Anne and Buys, Yvonne M and Trope, Graham and Hudson, Christopher (2014) The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. In: ARVO 2014, May 4 – 8, 2014, Orlando, FL, USA. (Unpublished) |
| spellingShingle | RE Ophthalmology Flanagan, John G Yusof, Firdaus Cheng, Richard Tayyari, Faryan Espahbodi, Nadia Khuu, Lee-Anne Buys, Yvonne M Trope, Graham Hudson, Christopher The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title | The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title_full | The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title_fullStr | The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title_full_unstemmed | The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title_short | The relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| title_sort | relationship between retinal nerve fiber layer thickness and total retinal blood flow in primary open angle glaucoma. |
| topic | RE Ophthalmology |
| url | http://irep.iium.edu.my/40378/ http://irep.iium.edu.my/40378/1/Abstract_FYA_JF_ARVO_2014.pdf http://irep.iium.edu.my/40378/4/ARVO_frontf_2014.pdf |