Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats
Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO...
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| Format: | Article |
| Language: | English |
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Anatomical Society of India.
2014
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| Online Access: | http://irep.iium.edu.my/40353/ http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf |
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| author | Saxena, Anil Kumar Phyu, Hnin P. Al-Ani, Imad Matloub Dally Talib, Norlelawati A. |
| author_facet | Saxena, Anil Kumar Phyu, Hnin P. Al-Ani, Imad Matloub Dally Talib, Norlelawati A. |
| author_sort | Saxena, Anil Kumar |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in
chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries
ligation (2VO) in rats.
Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated
2VO group “2VO” and honey treated 2VO group “2VO þ H”. At 10th week of
2VO surgery, all the rat were sacrificed, brains were dissected out, the right hemisphere
was processed for histological study, neuronal counts were performed on cresyl violetstained
sections, the number of viable neurons in CA-1 region of the hippocampus were
analysed and counted.
Results: There were damaged, distorted, irregular cells with shrunken cytoplasm and dark
pykonotic nuclei in “2VO” rats. Treatment of rats with honey restored the hippocampal
cells to their normal structure and reduced loss of neurons in “2VO þ H” rats as compared
with “2VO” rats.
Discussion: This study shows that Malaysian Tualang honey might have therapeutic potential
for the treatment of chronic cerebral hypoperfusion related neurodegenerative
disorders |
| first_indexed | 2025-11-14T15:57:31Z |
| format | Article |
| id | iium-40353 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:57:31Z |
| publishDate | 2014 |
| publisher | Anatomical Society of India. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-403532018-05-23T07:04:12Z http://irep.iium.edu.my/40353/ Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Phyu, Hnin P. Al-Ani, Imad Matloub Dally Talib, Norlelawati A. QM Human anatomy QP Physiology RB Pathology RM214 Diet therapy. Diet and dietectics in disease RM300 Drugs and their action Introduction: To investigate the neuroprotective potential of Malaysian Tualang honey in chronic cerebral hypoperfusion induced by permanent bilateral common carotid arteries ligation (2VO) in rats. Methods: Rats were randomly divided into three groups (n ¼ 10); sham control, honeyuntreated 2VO group “2VO” and honey treated 2VO group “2VO þ H”. At 10th week of 2VO surgery, all the rat were sacrificed, brains were dissected out, the right hemisphere was processed for histological study, neuronal counts were performed on cresyl violetstained sections, the number of viable neurons in CA-1 region of the hippocampus were analysed and counted. Results: There were damaged, distorted, irregular cells with shrunken cytoplasm and dark pykonotic nuclei in “2VO” rats. Treatment of rats with honey restored the hippocampal cells to their normal structure and reduced loss of neurons in “2VO þ H” rats as compared with “2VO” rats. Discussion: This study shows that Malaysian Tualang honey might have therapeutic potential for the treatment of chronic cerebral hypoperfusion related neurodegenerative disorders Anatomical Society of India. 2014-12-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf Saxena, Anil Kumar and Phyu, Hnin P. and Al-Ani, Imad Matloub Dally and Talib, Norlelawati A. (2014) Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats. Journal of the Anatomical Society of India, 63 (Sp iss). pp. 151-155. ISSN 0003-2778 (In Press) |
| spellingShingle | QM Human anatomy QP Physiology RB Pathology RM214 Diet therapy. Diet and dietectics in disease RM300 Drugs and their action Saxena, Anil Kumar Phyu, Hnin P. Al-Ani, Imad Matloub Dally Talib, Norlelawati A. Potential protective effect of honey against chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title | Potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| title_full | Potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| title_fullStr | Potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| title_full_unstemmed | Potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| title_short | Potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| title_sort | potential protective effect of honey against chronic
cerebral hypoperfusion-induced neurodegeneration
in rats |
| topic | QM Human anatomy QP Physiology RB Pathology RM214 Diet therapy. Diet and dietectics in disease RM300 Drugs and their action |
| url | http://irep.iium.edu.my/40353/ http://irep.iium.edu.my/40353/1/Potential_protective_effect_of_honey.pdf |