Microscopic diffusion properties of fixed breast tissue: preliminary findings
Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
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Wiley
2014
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| Online Access: | http://irep.iium.edu.my/40078/ http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf |
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| author | Norddin, Narina Power, Carl Watson, Geoffrey Cowin, Gary Kurniawan, Nyoman Gluch, Laurence Bourne, Roger |
| author_facet | Norddin, Narina Power, Carl Watson, Geoffrey Cowin, Gary Kurniawan, Nyoman Gluch, Laurence Bourne, Roger |
| author_sort | Norddin, Narina |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose: To investigate the microscopic diffusion properties
of formalin-fixed breast tissue.
Methods: Diffusion microimaging was performed at 16.4T with
40-mm isotropic voxels on two normal and two cancer tissue
samples from four patients. Results were correlated with histology
of the samples.
Results: Diffusion-weighted images and mean diffusivity maps
demonstrated distinct diffusivity differences between breast
tissue components. Mean diffusivity (MD) in normal tissue was
0.5960.24 mm2/ms for gland lobule (voxels containing epithelium
and intralobular stroma) and 1.2360.34 mm2/ms for interlobular
fibrous stroma. In the cancer samples,
MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels
contain epithelium and intralobular stroma) and 0.6160.35
mm2/ms for ductal carcinoma in situ. There were significant
MD differences between all tissue components (P<0.005),
except between gland lobule and ductal carcinoma in situ
(P¼0.71). The low diffusivity of epithelium-rich cancer tissue
and of normal epithelium relative to its supporting fibrous
stroma was similar to that reported for prostate tissue and the
esophageal wall.
Conclusion: Diffusion microimaging demonstrates distinct diffusivity
differences between breast tissue glandular structures.
Low diffusivity may be a distinctive feature of mammalian epithelia. |
| first_indexed | 2025-11-14T15:56:47Z |
| format | Article |
| id | iium-40078 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:56:47Z |
| publishDate | 2014 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-400782018-05-23T03:28:46Z http://irep.iium.edu.my/40078/ Microscopic diffusion properties of fixed breast tissue: preliminary findings Norddin, Narina Power, Carl Watson, Geoffrey Cowin, Gary Kurniawan, Nyoman Gluch, Laurence Bourne, Roger R Medicine (General) Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples. Results: Diffusion-weighted images and mean diffusivity maps demonstrated distinct diffusivity differences between breast tissue components. Mean diffusivity (MD) in normal tissue was 0.5960.24 mm2/ms for gland lobule (voxels containing epithelium and intralobular stroma) and 1.2360.34 mm2/ms for interlobular fibrous stroma. In the cancer samples, MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels contain epithelium and intralobular stroma) and 0.6160.35 mm2/ms for ductal carcinoma in situ. There were significant MD differences between all tissue components (P<0.005), except between gland lobule and ductal carcinoma in situ (P¼0.71). The low diffusivity of epithelium-rich cancer tissue and of normal epithelium relative to its supporting fibrous stroma was similar to that reported for prostate tissue and the esophageal wall. Conclusion: Diffusion microimaging demonstrates distinct diffusivity differences between breast tissue glandular structures. Low diffusivity may be a distinctive feature of mammalian epithelia. Wiley 2014-12-17 Article PeerReviewed application/pdf en http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf application/pdf en http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf Norddin, Narina and Power, Carl and Watson, Geoffrey and Cowin, Gary and Kurniawan, Nyoman and Gluch, Laurence and Bourne, Roger (2014) Microscopic diffusion properties of fixed breast tissue: preliminary findings. Magnetic Resonance in Medicine, xx (xx). pp. 1-7. (In Press) http://onlinelibrary.wiley.com/doi/10.1002/mrm.25555/abstract 10.1002/mrm.25555 |
| spellingShingle | R Medicine (General) Norddin, Narina Power, Carl Watson, Geoffrey Cowin, Gary Kurniawan, Nyoman Gluch, Laurence Bourne, Roger Microscopic diffusion properties of fixed breast tissue: preliminary findings |
| title | Microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| title_full | Microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| title_fullStr | Microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| title_full_unstemmed | Microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| title_short | Microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| title_sort | microscopic diffusion properties of fixed breast tissue:
preliminary findings |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/40078/ http://irep.iium.edu.my/40078/ http://irep.iium.edu.my/40078/ http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf |