Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl
Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out....
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| Format: | Proceeding Paper |
| Language: | English English |
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2014
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| Online Access: | http://irep.iium.edu.my/40051/ http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf |
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| author | Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini |
| author_facet | Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini |
| author_sort | Harun, Aiza |
| building | IIUM Repository |
| collection | Online Access |
| description | Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out. Our previous study revealed that methanol extract of E. spiralis stem bark exhibited promising antifungal activity against three dermatophyte strains, namely Trichophyton mentagrophytes ATCC 9533, Trichophyton tonsurans ATCC 28942 and Microsporum Gypseum ATCC 24102 that cause skin infection. This study was performed to elucidate the structure of active constituent known as ester saponin from the active fraction of E. spiralis stem bark. The factions were prepared using fractionation process and repeated antifungel test was conducted to identify the most active fraction. The structure elucidation of this compound was based on spectroscopis data (1H, 13C NMR, HMQC, HMBC and DEPT135) and comparison with literature. on the basis of spectroscopis analysis, the compound was identified as 28-α,L-rhamnopyranosyl-18,21,22-trihydroxy-12-en-29-(2-acetylamino-β-Dglucopyranosyl)triterpene ester. The current study provides important baseline information for the use of E. spiralis for the treatment of skin infection caused by the microorganism investigated in this study. |
| first_indexed | 2025-11-14T15:56:46Z |
| format | Proceeding Paper |
| id | iium-40051 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:56:46Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-400512015-01-06T07:34:26Z http://irep.iium.edu.my/40051/ Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini QD Chemistry Entada spiralis ridl (lenguminoceae) is a liana or woody climber that grows in the wild in Malaysia and is known locally as "Beluru" or "Sintok". The isolation and characterization of the chemical constituent from an active fraction of E. spiralis stem bark has been carried out. Our previous study revealed that methanol extract of E. spiralis stem bark exhibited promising antifungal activity against three dermatophyte strains, namely Trichophyton mentagrophytes ATCC 9533, Trichophyton tonsurans ATCC 28942 and Microsporum Gypseum ATCC 24102 that cause skin infection. This study was performed to elucidate the structure of active constituent known as ester saponin from the active fraction of E. spiralis stem bark. The factions were prepared using fractionation process and repeated antifungel test was conducted to identify the most active fraction. The structure elucidation of this compound was based on spectroscopis data (1H, 13C NMR, HMQC, HMBC and DEPT135) and comparison with literature. on the basis of spectroscopis analysis, the compound was identified as 28-α,L-rhamnopyranosyl-18,21,22-trihydroxy-12-en-29-(2-acetylamino-β-Dglucopyranosyl)triterpene ester. The current study provides important baseline information for the use of E. spiralis for the treatment of skin infection caused by the microorganism investigated in this study. 2014 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf application/pdf en http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf Harun, Aiza and Mat So'ad, Siti Zaiton and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2014) Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl. In: Regional Conference On Science, Technology & Social Sciences , 23rd - 25th November 2014, Cameron Highlands, Pahang. (Unpublished) |
| spellingShingle | QD Chemistry Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title | Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title_full | Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title_fullStr | Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title_full_unstemmed | Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title_short | Bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| title_sort | bioassay guided isolation of an antidermatophytic active constituents from the stembarks of entada spiralis ridl |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/40051/ http://irep.iium.edu.my/40051/1/Abstract_RCSTSS2014aiza_2014.pdf http://irep.iium.edu.my/40051/2/Abstractrcstss2014.pdf |