Kesan in vitro rilmenidine ke atas rembesan insulin

This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak...

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Main Authors: Hashim, Rosnani, Abdul Razak, Tariq, Hashim, Suhaimi
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2003
Subjects:
Online Access:http://irep.iium.edu.my/400/
http://irep.iium.edu.my/400/1/Jurnal_Sains_Kesihatan_Malaysia_Jilid_I_2003.pdf
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author Hashim, Rosnani
Abdul Razak, Tariq
Hashim, Suhaimi
author_facet Hashim, Rosnani
Abdul Razak, Tariq
Hashim, Suhaimi
author_sort Hashim, Rosnani
building IIUM Repository
collection Online Access
description This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.
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language English
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spelling iium-4002011-08-08T00:44:35Z http://irep.iium.edu.my/400/ Kesan in vitro rilmenidine ke atas rembesan insulin Hashim, Rosnani Abdul Razak, Tariq Hashim, Suhaimi RM Therapeutics. Pharmacology This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. Penerbit Universiti Kebangsaan Malaysia 2003 Article PeerReviewed application/pdf en http://irep.iium.edu.my/400/1/Jurnal_Sains_Kesihatan_Malaysia_Jilid_I_2003.pdf Hashim, Rosnani and Abdul Razak, Tariq and Hashim, Suhaimi (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1. pp. 1-7. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal.html
spellingShingle RM Therapeutics. Pharmacology
Hashim, Rosnani
Abdul Razak, Tariq
Hashim, Suhaimi
Kesan in vitro rilmenidine ke atas rembesan insulin
title Kesan in vitro rilmenidine ke atas rembesan insulin
title_full Kesan in vitro rilmenidine ke atas rembesan insulin
title_fullStr Kesan in vitro rilmenidine ke atas rembesan insulin
title_full_unstemmed Kesan in vitro rilmenidine ke atas rembesan insulin
title_short Kesan in vitro rilmenidine ke atas rembesan insulin
title_sort kesan in vitro rilmenidine ke atas rembesan insulin
topic RM Therapeutics. Pharmacology
url http://irep.iium.edu.my/400/
http://irep.iium.edu.my/400/
http://irep.iium.edu.my/400/1/Jurnal_Sains_Kesihatan_Malaysia_Jilid_I_2003.pdf