Evaluation of antimalaria activity and acute toxicity of xetospongia sp
We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and establ...
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| Format: | Article |
| Language: | English |
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Science Publications
2013
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| Online Access: | http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf |
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| author | Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah |
| author_facet | Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah |
| author_sort | Abdillah, Syamsudin |
| building | IIUM Repository |
| collection | Online Access |
| description | We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1. |
| first_indexed | 2025-11-14T15:56:32Z |
| format | Article |
| id | iium-39966 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:56:32Z |
| publishDate | 2013 |
| publisher | Science Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-399662014-12-16T03:18:09Z http://irep.iium.edu.my/39966/ Evaluation of antimalaria activity and acute toxicity of xetospongia sp Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah RC Internal medicine We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant antimalarial activity both in the 4-day early infection test and in the established infection and they were found to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1. Science Publications 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf Abdillah, Syamsudin and Ahmad, Rahmatul Wahidah and Parama Cita, Yatnita and Mohd Noor, Noriah (2013) Evaluation of antimalaria activity and acute toxicity of xetospongia sp. American Journal of Pharmacology and Toxicology , 8 (2). pp. 83-88. ISSN 1557-4962 http://thescipub.com/abstract/10.3844/ajptsp.2013.83.88 10.3844/ajptsp.2013.83.88 |
| spellingShingle | RC Internal medicine Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Parama Cita, Yatnita Mohd Noor, Noriah Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title | Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title_full | Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title_fullStr | Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title_full_unstemmed | Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title_short | Evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| title_sort | evaluation of antimalaria activity and acute toxicity of xetospongia sp |
| topic | RC Internal medicine |
| url | http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/ http://irep.iium.edu.my/39966/1/ajptsp.2013.83.88.pdf |