Antimalarial activity of Neopetrosia exigua extract in mice
Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its ant...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of Pharmaceutical Innovators
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/39965/ http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf |
| _version_ | 1848781876297203712 |
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| author | Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Muzaki, Farid Kamal Mohd Noor, Noriah |
| author_facet | Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Muzaki, Farid Kamal Mohd Noor, Noriah |
| author_sort | Abdillah, Syamsudin |
| building | IIUM Repository |
| collection | Online Access |
| description | Objective:
To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test.
Methods:
The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei during early infection.
The acute toxicity of the extract was also investigated. At the end of 14 days, mice were sacrificed for histopathology study.
Results:
The extract of Neopetrosia exigua demonstrated significant (
p <0.05) schizonticidal activity. The acute toxicity test showed that the extract of Neopetrosia exigua is toxicological safe by oral administration. Histopathological study revealed normal architecture of kidney and liver of mice. |
| first_indexed | 2025-11-14T15:56:32Z |
| format | Article |
| id | iium-39965 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:56:32Z |
| publishDate | 2013 |
| publisher | Association of Pharmaceutical Innovators |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-399652014-12-16T03:02:34Z http://irep.iium.edu.my/39965/ Antimalarial activity of Neopetrosia exigua extract in mice Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Muzaki, Farid Kamal Mohd Noor, Noriah RC Internal medicine Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei during early infection. The acute toxicity of the extract was also investigated. At the end of 14 days, mice were sacrificed for histopathology study. Results: The extract of Neopetrosia exigua demonstrated significant ( p <0.05) schizonticidal activity. The acute toxicity test showed that the extract of Neopetrosia exigua is toxicological safe by oral administration. Histopathological study revealed normal architecture of kidney and liver of mice. Association of Pharmaceutical Innovators 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf Abdillah, Syamsudin and Ahmad, Rahmatul Wahidah and Muzaki, Farid Kamal and Mohd Noor, Noriah (2013) Antimalarial activity of Neopetrosia exigua extract in mice. Journal of Pharmacy Research , 6 (8). pp. 799-803. ISSN 0974-6943 http://www.sciencedirect.com/science/article/pii/S0974694313003149 10.1016/j.jopr.2013.08.001 |
| spellingShingle | RC Internal medicine Abdillah, Syamsudin Ahmad, Rahmatul Wahidah Muzaki, Farid Kamal Mohd Noor, Noriah Antimalarial activity of Neopetrosia exigua extract in mice |
| title | Antimalarial activity of Neopetrosia exigua extract in mice |
| title_full | Antimalarial activity of Neopetrosia exigua extract in mice |
| title_fullStr | Antimalarial activity of Neopetrosia exigua extract in mice |
| title_full_unstemmed | Antimalarial activity of Neopetrosia exigua extract in mice |
| title_short | Antimalarial activity of Neopetrosia exigua extract in mice |
| title_sort | antimalarial activity of neopetrosia exigua extract in mice |
| topic | RC Internal medicine |
| url | http://irep.iium.edu.my/39965/ http://irep.iium.edu.my/39965/ http://irep.iium.edu.my/39965/ http://irep.iium.edu.my/39965/1/1-s2.0-S0974694313003149-main.pdf |