Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines
Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted us...
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| Format: | Proceeding Paper |
| Language: | English English English English |
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2014
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| Online Access: | http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf |
| _version_ | 1848781801526394880 |
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| author | Hamidon, Hanisuhana Bakhtiar, M. Taher |
| author_facet | Hamidon, Hanisuhana Bakhtiar, M. Taher |
| author_sort | Hamidon, Hanisuhana |
| building | IIUM Repository |
| collection | Online Access |
| description | Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. Cell viability study of extracts against cell line was first done using MTT assay. Then, chosen safe concentration was used in the nitric oxide production study in LPS-stimulated cells that based on Griess reagent reaction. The result of cytotoxicity study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. As conclusion, these finding indicated that G. xanthochymus extracts may become interesting candidate for treatment of cancer and inflammation. |
| first_indexed | 2025-11-14T15:55:20Z |
| format | Proceeding Paper |
| id | iium-39531 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T15:55:20Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-395312015-01-06T10:34:41Z http://irep.iium.edu.my/39531/ Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines Hamidon, Hanisuhana Bakhtiar, M. Taher RS Pharmacy and materia medica Natural products have been recognized and utilized by humans in management of disease, injuries and other health problems. This study was conducted to evaluate cytotoxic and anti- inflammatory activities of Garcinia xanthochymus extracts on cell lines. Roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. Cell viability study of extracts against cell line was first done using MTT assay. Then, chosen safe concentration was used in the nitric oxide production study in LPS-stimulated cells that based on Griess reagent reaction. The result of cytotoxicity study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. As conclusion, these finding indicated that G. xanthochymus extracts may become interesting candidate for treatment of cancer and inflammation. 2014 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf application/pdf en http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf application/pdf en http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx application/pdf en http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf Hamidon, Hanisuhana and Bakhtiar, M. Taher (2014) Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines. In: International Health Conference IIUM 2014, 3rd - 4th December 2014, Kuantan, Pahang. (Unpublished) http://www.iium.edu.my/ihci |
| spellingShingle | RS Pharmacy and materia medica Hamidon, Hanisuhana Bakhtiar, M. Taher Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title | Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title_full | Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title_fullStr | Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title_full_unstemmed | Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title_short | Cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| title_sort | cytotoxicity and anti-inflammatory activities of garcinia xanthochymus extracts on cell lines |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/ http://irep.iium.edu.my/39531/1/IHCI_2014_Programme_Book.pdf http://irep.iium.edu.my/39531/2/IHCI_2014_Abstract_Book.pdf http://irep.iium.edu.my/39531/3/IHCI_poster_-_Anis-2.pptx http://irep.iium.edu.my/39531/8/IHCI_poster_-_Anis-2.pdf |