Particle formation and micronization using non-conventional techniques- review
Due to growing concerns regarding health, safety and the environment, non-conventional methods for particle formation and micronization that are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 '...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier B.V
2014
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| Online Access: | http://irep.iium.edu.my/38952/ http://irep.iium.edu.my/38952/1/JSF-paper-2014.pdf http://irep.iium.edu.my/38952/4/38952_Particle%20formation%20and%20micronization.SCOPUS.pdf |
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| author | Karim, Fahim Tamzeedul Sarker, Md. Zaidul Islam Abu Bakar, Mohd Rushdi U.M., Salim Awang, Mohamed Ferdosh, Sahena Khan Chowdhury, Ahmed Jalal Sharif, K. M. Hossain, Md Sohrab |
| author_facet | Karim, Fahim Tamzeedul Sarker, Md. Zaidul Islam Abu Bakar, Mohd Rushdi U.M., Salim Awang, Mohamed Ferdosh, Sahena Khan Chowdhury, Ahmed Jalal Sharif, K. M. Hossain, Md Sohrab |
| author_sort | Karim, Fahim Tamzeedul |
| building | IIUM Repository |
| collection | Online Access |
| description | Due to growing concerns regarding health, safety and the environment, non-conventional methods for
particle formation and micronization that are either solvent-less or use environmentally acceptable
solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 'C, P > 7.3 MPa)
has been used in food and pharmaceutical industries to minimize the use of organic solvents, produce
new food products, produce environmentally superior food products and to process and micronize
(0.1–5mm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body.
Techniques that use sc CO2 eliminate inherent drawbacks of conventional methods such as thermal or
mechanical degradation of the product, poor control of the particle size and morphology, lack of
brittleness of some polymers and low encapsulation efficiency. Severaltechniques have been reported for
the particle formation and micronization using supercritical fluids that have been successfully scaled up
for commercial use. Supercritical CO2 has also been used to develop applications for medicines, essential
oils, vitamins, food grade polymers, catalysts and pigments. This review highlights the process
mechanism of supercritical fluid based techniques as well as some applications on particle formation and
micronization. |
| first_indexed | 2025-11-14T15:53:42Z |
| format | Article |
| id | iium-38952 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:53:42Z |
| publishDate | 2014 |
| publisher | Elsevier B.V |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-389522019-10-09T08:20:14Z http://irep.iium.edu.my/38952/ Particle formation and micronization using non-conventional techniques- review Karim, Fahim Tamzeedul Sarker, Md. Zaidul Islam Abu Bakar, Mohd Rushdi U.M., Salim Awang, Mohamed Ferdosh, Sahena Khan Chowdhury, Ahmed Jalal Sharif, K. M. Hossain, Md Sohrab Q Science (General) T Technology (General) Due to growing concerns regarding health, safety and the environment, non-conventional methods for particle formation and micronization that are either solvent-less or use environmentally acceptable solvents such as carbon dioxide have come into favor. Supercritical CO2 (sc CO2) (T > 31.1 'C, P > 7.3 MPa) has been used in food and pharmaceutical industries to minimize the use of organic solvents, produce new food products, produce environmentally superior food products and to process and micronize (0.1–5mm) pharmaceuticals. Control of particle size increases the dissolution rate of drugs into the body. Techniques that use sc CO2 eliminate inherent drawbacks of conventional methods such as thermal or mechanical degradation of the product, poor control of the particle size and morphology, lack of brittleness of some polymers and low encapsulation efficiency. Severaltechniques have been reported for the particle formation and micronization using supercritical fluids that have been successfully scaled up for commercial use. Supercritical CO2 has also been used to develop applications for medicines, essential oils, vitamins, food grade polymers, catalysts and pigments. This review highlights the process mechanism of supercritical fluid based techniques as well as some applications on particle formation and micronization. Elsevier B.V 2014-10-22 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38952/1/JSF-paper-2014.pdf application/pdf en http://irep.iium.edu.my/38952/4/38952_Particle%20formation%20and%20micronization.SCOPUS.pdf Karim, Fahim Tamzeedul and Sarker, Md. Zaidul Islam and Abu Bakar, Mohd Rushdi and U.M., Salim and Awang, Mohamed and Ferdosh, Sahena and Khan Chowdhury, Ahmed Jalal and Sharif, K. M. and Hossain, Md Sohrab (2014) Particle formation and micronization using non-conventional techniques- review. Chemical Engineering and Processing: Process Intensification, 86 (2014). pp. 47-52. ISSN 0255-2701 http://www.journals.elsevier.com/chemical-engineering-and-processing-process-intensification/ |
| spellingShingle | Q Science (General) T Technology (General) Karim, Fahim Tamzeedul Sarker, Md. Zaidul Islam Abu Bakar, Mohd Rushdi U.M., Salim Awang, Mohamed Ferdosh, Sahena Khan Chowdhury, Ahmed Jalal Sharif, K. M. Hossain, Md Sohrab Particle formation and micronization using non-conventional techniques- review |
| title | Particle formation and micronization using non-conventional
techniques- review |
| title_full | Particle formation and micronization using non-conventional
techniques- review |
| title_fullStr | Particle formation and micronization using non-conventional
techniques- review |
| title_full_unstemmed | Particle formation and micronization using non-conventional
techniques- review |
| title_short | Particle formation and micronization using non-conventional
techniques- review |
| title_sort | particle formation and micronization using non-conventional
techniques- review |
| topic | Q Science (General) T Technology (General) |
| url | http://irep.iium.edu.my/38952/ http://irep.iium.edu.my/38952/ http://irep.iium.edu.my/38952/1/JSF-paper-2014.pdf http://irep.iium.edu.my/38952/4/38952_Particle%20formation%20and%20micronization.SCOPUS.pdf |