Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga
Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all...
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| Format: | Article |
| Language: | English |
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Oriental Scientific Publishing Co.
2014
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| Online Access: | http://irep.iium.edu.my/38610/ http://irep.iium.edu.my/38610/1/EPMC_EPHC_OJCV030I03P1037-1043.pdf |
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| author | Omar, Muhammad Nor Mohd Hasali, Nor Hazwani Alfarra, Helmi Yousif Yarmo, Mohd Ambar Zuberdi, Ahmad Muzammil |
| author_facet | Omar, Muhammad Nor Mohd Hasali, Nor Hazwani Alfarra, Helmi Yousif Yarmo, Mohd Ambar Zuberdi, Ahmad Muzammil |
| author_sort | Omar, Muhammad Nor |
| building | IIUM Repository |
| collection | Online Access |
| description | Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active against both Staphylococcus aureus and Bacillus cereus at MIC 333 μg/ml while against Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 μg/ml. It was also shown that EPHC exhibited more growth inhibition potential than EPMC. Besides that, EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 μg/mL while EPMC did not show killing potential toward the tested microorganisms. |
| first_indexed | 2025-11-14T15:52:43Z |
| format | Article |
| id | iium-38610 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:52:43Z |
| publishDate | 2014 |
| publisher | Oriental Scientific Publishing Co. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-386102018-06-19T01:57:42Z http://irep.iium.edu.my/38610/ Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga Omar, Muhammad Nor Mohd Hasali, Nor Hazwani Alfarra, Helmi Yousif Yarmo, Mohd Ambar Zuberdi, Ahmad Muzammil QR Microbiology Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed to ethyl p-hydroxycinnamate (EPHC) using Aspergillus niger. The EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active against both Staphylococcus aureus and Bacillus cereus at MIC 333 μg/ml while against Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 μg/ml. It was also shown that EPHC exhibited more growth inhibition potential than EPMC. Besides that, EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 μg/mL while EPMC did not show killing potential toward the tested microorganisms. Oriental Scientific Publishing Co. 2014-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38610/1/EPMC_EPHC_OJCV030I03P1037-1043.pdf Omar, Muhammad Nor and Mohd Hasali, Nor Hazwani and Alfarra, Helmi Yousif and Yarmo, Mohd Ambar and Zuberdi, Ahmad Muzammil (2014) Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga. Oriental Journal of Chemistry, 30 (3). pp. 1037-1043. ISSN 0970 - 020X (P), 2231-5039 (O) http://www.orientjchem.org/pdf/vol30no3/OJCV030I03P1037-1043.pdf 10.13005/ojc/300315 |
| spellingShingle | QR Microbiology Omar, Muhammad Nor Mohd Hasali, Nor Hazwani Alfarra, Helmi Yousif Yarmo, Mohd Ambar Zuberdi, Ahmad Muzammil Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title | Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title_full | Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title_fullStr | Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title_full_unstemmed | Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title_short | Antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from Kaempferia Galanga |
| title_sort | antimicrobial activity and microbial transformation of ethyl p-methoxycinnamate extracted from kaempferia galanga |
| topic | QR Microbiology |
| url | http://irep.iium.edu.my/38610/ http://irep.iium.edu.my/38610/ http://irep.iium.edu.my/38610/ http://irep.iium.edu.my/38610/1/EPMC_EPHC_OJCV030I03P1037-1043.pdf |