Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis
Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associat...
| Main Authors: | , , , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf |
| _version_ | 1848781500526362624 |
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| author | Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. |
| author_facet | Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. |
| author_sort | Abdul Aziz, Mohd. Hafiz |
| building | IIUM Repository |
| collection | Online Access |
| description | Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associated penetration into interstitial fluid (ISF) of subcutaneous tissue. We also sought to describe risk factors for not achieving PK/pharmacodynamic (PK/PD) targets in critically ill patients with sepsis. |
| first_indexed | 2025-11-14T15:50:33Z |
| format | Proceeding Paper |
| id | iium-37925 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:50:33Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-379252018-06-25T01:00:16Z http://irep.iium.edu.my/37925/ Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. RM Therapeutics. Pharmacology RS Pharmacy and materia medica Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associated penetration into interstitial fluid (ISF) of subcutaneous tissue. We also sought to describe risk factors for not achieving PK/pharmacodynamic (PK/PD) targets in critically ill patients with sepsis. 2014 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf application/pdf en http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf Abdul Aziz, Mohd. Hafiz and Udy, Andrew A. and Wallis, Steven C. and Roberts, Michael S. and Lipman, Jeffrey and Roberts, Jason A. (2014) Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis. In: 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2014), 10th-13th May 2014, Barcelona, Spain. http://2014.eccmid.org/ |
| spellingShingle | RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abdul Aziz, Mohd. Hafiz Udy, Andrew A. Wallis, Steven C. Roberts, Michael S. Lipman, Jeffrey Roberts, Jason A. Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title | Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title_full | Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title_fullStr | Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title_full_unstemmed | Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title_short | Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| title_sort | plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis |
| topic | RM Therapeutics. Pharmacology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/ http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf |