A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2010
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf |
| _version_ | 1848775700598751232 |
|---|---|
| author | Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. |
| author_facet | Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. |
| author_sort | Abu Bakar, Mohd Rushdi |
| building | IIUM Repository |
| collection | Online Access |
| description | A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to be useful in describing and verifying thermal events. The approach provides a unique insight into the polymorphic transformations and thermal behaviour exhibited by this compound. The results of the experiments show that sulfathiazole tends to crystallise as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed. |
| first_indexed | 2025-11-14T14:18:22Z |
| format | Article |
| id | iium-375 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:18:22Z |
| publishDate | 2010 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-3752011-07-11T04:33:04Z http://irep.iium.edu.my/375/ A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. QD Chemistry TP Chemical technology A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to be useful in describing and verifying thermal events. The approach provides a unique insight into the polymorphic transformations and thermal behaviour exhibited by this compound. The results of the experiments show that sulfathiazole tends to crystallise as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed. Springer 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. and Rielly, Chris D. (2010) A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism. Journal of Thermal Analysis and Calorimetry, 99 (2). pp. 609-619. ISSN 1388-6150 http://www.springerlink.com/content/b2h7611258473620/ doi:10.1007/s10973-009-0001-z |
| spellingShingle | QD Chemistry TP Chemical technology Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title | A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title_full | A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title_fullStr | A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title_full_unstemmed | A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title_short | A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| title_sort | combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism |
| topic | QD Chemistry TP Chemical technology |
| url | http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf |