Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes
Introduction: The rates of cure for pelvic tumours are still lower compared to tumours involving the long bones even with advancement in treatment modalities. Safe surgical margins, an important prognostic factor for oncologic outcomes, are difficult to achieve when performing surgical resections fo...
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| Format: | Proceeding Paper |
| Language: | English English |
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2014
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| Online Access: | http://irep.iium.edu.my/36932/ http://irep.iium.edu.my/36932/1/IRIE_PROGRAMME_BOOK_2.pdf http://irep.iium.edu.my/36932/2/Poster_Ariff_%282%29_-_Pelvic_Resection.pdf |
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| author | Sharifudin, Mohd Ariff Wan Ismail, Wan Faisham Numan Wan, Zulmi Mat Zin, Nor Azman Mohamed Amin, Mohamed Azril Goh, Kian Liang |
| author_facet | Sharifudin, Mohd Ariff Wan Ismail, Wan Faisham Numan Wan, Zulmi Mat Zin, Nor Azman Mohamed Amin, Mohamed Azril Goh, Kian Liang |
| author_sort | Sharifudin, Mohd Ariff |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: The rates of cure for pelvic tumours are still lower compared to tumours involving the long bones even with advancement in treatment modalities. Safe surgical margins, an important prognostic factor for oncologic outcomes, are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated the accuracy of surgical margins achieved in pelvic tumour resections, its associated factors, as well as the oncologic outcomes. Materials and Methods: 64 cases of pelvic tumours of various types, whom underwent internal (limb-salvage) or external hemipelvectomy in a single tumour referral center were included. Various clinicopathologic factors were analyzed in relation to achieving a negative microscopic margin in tumour resections. Analysis included survival time to local recurrence, distant metastasis, and disease-specific death of patients, as well as factors associated with the oncologic outcomes. Results: Mean age at time of surgery was 39.8 years (range 8 to 79 years). Majority of cases were primary tumours (76.56%), mostly were chondrosarcoma (n=14) and osteosarcoma (n=13). 23 patients underwent external hemipelvectomy and 41 patients subjected for internal hemipelvectomy of various types of resections. Majority (71.88%) of cases were treated with curative intention. 14 of 37 cases (37.84%) attempted for wide resection had positive microscopic margins. Incidence of positive microscopic margin was higher in cases with wide contaminated margins (56.25%). Factors associated with positive microscopic margin include tumour occurrence, tumour volume, tumour stage, types of surgery (amputation or limb-salvage) and types of pelvic resections. Local and distant recurrence rate were higher when margins were positive. Paradoxically the disease-specific death rate was lower in cases with positive margins. Conclusion: The probability of achieving a clear microscopic margin in attempted wide resections was as low as 50% only, similar to a previous published experimental study. Internal hemipelvectomy provides significantly better disease-specific survival rate, hence justified with proper indication and selection of patients. Microscopic margin was a prognostic factor for all three primary endpoints of this study, but was not statistically proven as an independent prognostic factor. |
| first_indexed | 2025-11-14T15:47:44Z |
| format | Proceeding Paper |
| id | iium-36932 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:47:44Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-369322018-12-20T00:20:16Z http://irep.iium.edu.my/36932/ Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes Sharifudin, Mohd Ariff Wan Ismail, Wan Faisham Numan Wan, Zulmi Mat Zin, Nor Azman Mohamed Amin, Mohamed Azril Goh, Kian Liang RC254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Introduction: The rates of cure for pelvic tumours are still lower compared to tumours involving the long bones even with advancement in treatment modalities. Safe surgical margins, an important prognostic factor for oncologic outcomes, are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated the accuracy of surgical margins achieved in pelvic tumour resections, its associated factors, as well as the oncologic outcomes. Materials and Methods: 64 cases of pelvic tumours of various types, whom underwent internal (limb-salvage) or external hemipelvectomy in a single tumour referral center were included. Various clinicopathologic factors were analyzed in relation to achieving a negative microscopic margin in tumour resections. Analysis included survival time to local recurrence, distant metastasis, and disease-specific death of patients, as well as factors associated with the oncologic outcomes. Results: Mean age at time of surgery was 39.8 years (range 8 to 79 years). Majority of cases were primary tumours (76.56%), mostly were chondrosarcoma (n=14) and osteosarcoma (n=13). 23 patients underwent external hemipelvectomy and 41 patients subjected for internal hemipelvectomy of various types of resections. Majority (71.88%) of cases were treated with curative intention. 14 of 37 cases (37.84%) attempted for wide resection had positive microscopic margins. Incidence of positive microscopic margin was higher in cases with wide contaminated margins (56.25%). Factors associated with positive microscopic margin include tumour occurrence, tumour volume, tumour stage, types of surgery (amputation or limb-salvage) and types of pelvic resections. Local and distant recurrence rate were higher when margins were positive. Paradoxically the disease-specific death rate was lower in cases with positive margins. Conclusion: The probability of achieving a clear microscopic margin in attempted wide resections was as low as 50% only, similar to a previous published experimental study. Internal hemipelvectomy provides significantly better disease-specific survival rate, hence justified with proper indication and selection of patients. Microscopic margin was a prognostic factor for all three primary endpoints of this study, but was not statistically proven as an independent prognostic factor. 2014 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/36932/1/IRIE_PROGRAMME_BOOK_2.pdf application/pdf en http://irep.iium.edu.my/36932/2/Poster_Ariff_%282%29_-_Pelvic_Resection.pdf Sharifudin, Mohd Ariff and Wan Ismail, Wan Faisham Numan and Wan, Zulmi and Mat Zin, Nor Azman and Mohamed Amin, Mohamed Azril and Goh, Kian Liang (2014) Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes. In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014), 11th -13th June 2014, Cultural Activity Center (CAC), Internatioanal Islamic University Malaysia. http://www.iium.edu.my/irie/14/ |
| spellingShingle | RC254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Sharifudin, Mohd Ariff Wan Ismail, Wan Faisham Numan Wan, Zulmi Mat Zin, Nor Azman Mohamed Amin, Mohamed Azril Goh, Kian Liang Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title | Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title_full | Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title_fullStr | Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title_full_unstemmed | Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title_short | Surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| title_sort | surgical inaccuracy or tumour-related pelvic resections and implications on the oncologic outcomes |
| topic | RC254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics |
| url | http://irep.iium.edu.my/36932/ http://irep.iium.edu.my/36932/ http://irep.iium.edu.my/36932/1/IRIE_PROGRAMME_BOOK_2.pdf http://irep.iium.edu.my/36932/2/Poster_Ariff_%282%29_-_Pelvic_Resection.pdf |