Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surfa...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/1/Published_paper.pdf |
| _version_ | 1848781205402550272 |
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| author | Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar |
| author_facet | Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar |
| author_sort | Senjoti, Faria Gias |
| building | IIUM Repository |
| collection | Online Access |
| description | Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. The optimized tablets were further characterized by surface morphology, drug release kinetics, accelerated stability study etc. The optimized tablets enabled to float for more than 24 h and sustained the drug release for 12 h. |
| first_indexed | 2025-11-14T15:45:52Z |
| format | Proceeding Paper |
| id | iium-36315 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:45:52Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-363152018-06-25T00:39:40Z http://irep.iium.edu.my/36315/ Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar RS Pharmacy and materia medica Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. The optimized tablets were further characterized by surface morphology, drug release kinetics, accelerated stability study etc. The optimized tablets enabled to float for more than 24 h and sustained the drug release for 12 h. 2014 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/36315/1/Published_paper.pdf Senjoti, Faria Gias and Jaffri, Juliana Md. and Mandal, Uttam Kumar (2014) Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix. In: International Conference on Pharmaceutical Sciences and Biomedical and Chemical Engineering, February 19 to 20, 2014, Kuala Lumpur. http://isro.eu.com/Mal_Proceed/pdf%2019.pdf |
| spellingShingle | RS Pharmacy and materia medica Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title | Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title_full | Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title_fullStr | Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title_full_unstemmed | Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title_short | Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix |
| title_sort | fabrication and optimization of gastro retentive drug delivery system with hpmc and polyethylene oxide (peo) matrix |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/1/Published_paper.pdf |