The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats w...
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| Format: | Article |
| Language: | English |
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Lippincott Williams & Wilkins
2009
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| Online Access: | http://irep.iium.edu.my/36103/ http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf |
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| author | Ku Zaifah, Norsidah Ahmad Yusof, Asmadi Ayob, Azizi Yusuf, Kamisah |
| author_facet | Ku Zaifah, Norsidah Ahmad Yusof, Asmadi Ayob, Azizi Yusuf, Kamisah |
| author_sort | Ku Zaifah, Norsidah |
| building | IIUM Repository |
| collection | Online Access |
| description | Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups two through six were fed 1% methionine diet for 10 weeks. From week six onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups three (M + Folate), four (M + TFR30), five (M + TRF60) and six (M + TRF150) respectively. Body weights were recorded weekly. No significant difference in body weight was recorded. Methionine diet (M) significantly raised the plasma homocysteine (tHcy level) and this was reduced by the supplementations of palm TRF at 150 mg/kg diet and folate. The dietary methionine increased aortic lipid peroxidation as shown by the increase in TBARS (604.0 +/- 51.0 pmol MDA/ mg protein, P < 0.05). - See more at: http://www.nursingcenter.com/lnc/JournalArticle?Article_ID=2412948&Journal_ID=1658605&Issue_ID=2412900#sthash.VqFndvF4.dpuf |
| first_indexed | 2025-11-14T15:45:11Z |
| format | Article |
| id | iium-36103 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:45:11Z |
| publishDate | 2009 |
| publisher | Lippincott Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-361032015-04-07T04:31:49Z http://irep.iium.edu.my/36103/ The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet Ku Zaifah, Norsidah Ahmad Yusof, Asmadi Ayob, Azizi Yusuf, Kamisah RM300 Drugs and their action Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups two through six were fed 1% methionine diet for 10 weeks. From week six onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups three (M + Folate), four (M + TFR30), five (M + TRF60) and six (M + TRF150) respectively. Body weights were recorded weekly. No significant difference in body weight was recorded. Methionine diet (M) significantly raised the plasma homocysteine (tHcy level) and this was reduced by the supplementations of palm TRF at 150 mg/kg diet and folate. The dietary methionine increased aortic lipid peroxidation as shown by the increase in TBARS (604.0 +/- 51.0 pmol MDA/ mg protein, P < 0.05). - See more at: http://www.nursingcenter.com/lnc/JournalArticle?Article_ID=2412948&Journal_ID=1658605&Issue_ID=2412900#sthash.VqFndvF4.dpuf Lippincott Williams & Wilkins 2009-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf Ku Zaifah, Norsidah and Ahmad Yusof, Asmadi and Ayob, Azizi and Yusuf, Kamisah (2009) The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. International Journal of Evidence-Based Healthcare, 7 (3). p. 214. ISSN 1744-1609 http://onlinelibrary.wiley.com/doi/10.1111/jbr.2009.7.issue-3/issuetoc 10.1111/j.1744-1609.2009.00141.x |
| spellingShingle | RM300 Drugs and their action Ku Zaifah, Norsidah Ahmad Yusof, Asmadi Ayob, Azizi Yusuf, Kamisah The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title | The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title_full | The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title_fullStr | The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title_full_unstemmed | The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title_short | The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| title_sort | effects of palm tocotrienol rich fraction (trf) on proatherosclerotic changes in aorta of rats fed a high methionine diet |
| topic | RM300 Drugs and their action |
| url | http://irep.iium.edu.my/36103/ http://irep.iium.edu.my/36103/ http://irep.iium.edu.my/36103/ http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf |