Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition
The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat we...
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| Format: | Proceeding Paper |
| Language: | English |
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2014
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| Online Access: | http://irep.iium.edu.my/35982/ http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf |
| _version_ | 1848781140954972160 |
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| author | Nafiu, Bidemi Abdulrazaq Rahman, Mohammad Tariqur |
| author_facet | Nafiu, Bidemi Abdulrazaq Rahman, Mohammad Tariqur |
| author_sort | Nafiu, Bidemi Abdulrazaq |
| building | IIUM Repository |
| collection | Online Access |
| description | The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat were topically treated twice/day with 20 μL of extract dissolved in deionised water (5 mg/mL) where Se2+ and Zn2+ was separately added at 0.1 μg/mg extract and 100 μM concentrations respectively. Control groups were treated with deionised water (negative) and solcoseryl (positive). The excised wound homogenate at day 4 and 10 post wounding was used to analyse antioxidants enzyme activities (catalase, superoxide dismutase, glutathione peroxidase) and lipid peroxidation. Se2+ added extract significantly (p< 0.05) reduced the wound size as compared to negative and positive controls throughout the observation period and on days 1 and 7 respectively. Positive control and the extract significantly (p< 0.05) reduced wound size on days 1-5 and 7-9 respectively. Se2+ added extract significantly (p< 0.05) increased the enzymes’ activities on day 4 and 10 compared to negative control and day 4 only when compared to positive control. Remaining treatments significantly (p< 0.05) increased activity of catalase on day 4 and 10 and superoxide dismutase on day 4 only when compared to negative control. All treatments significantly (p< 0.05) decreased lipid peroxidation at day 4 and 10 post wounding. Thus, Se2+ added papaya extracts provide increased protection against oxidative damage during wound repair.
Keywords: Papaya extract, wound healing, Se, Zn and antioxidant enzymes
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| first_indexed | 2025-11-14T15:44:50Z |
| format | Proceeding Paper |
| id | iium-35982 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:44:50Z |
| publishDate | 2014 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-359822014-03-12T09:14:03Z http://irep.iium.edu.my/35982/ Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition Nafiu, Bidemi Abdulrazaq Rahman, Mohammad Tariqur Q Science (General) The healing efficiency of cutaneous wound increases when Se2+ is added to the unripe papaya phosphate buffered saline (PBS) extract. This study investigated protection against oxidative damage in cutaneous wound by using Se2+ or Zn2+ added unripe papaya PBS extract; Induced cutaneous wound on rat were topically treated twice/day with 20 μL of extract dissolved in deionised water (5 mg/mL) where Se2+ and Zn2+ was separately added at 0.1 μg/mg extract and 100 μM concentrations respectively. Control groups were treated with deionised water (negative) and solcoseryl (positive). The excised wound homogenate at day 4 and 10 post wounding was used to analyse antioxidants enzyme activities (catalase, superoxide dismutase, glutathione peroxidase) and lipid peroxidation. Se2+ added extract significantly (p< 0.05) reduced the wound size as compared to negative and positive controls throughout the observation period and on days 1 and 7 respectively. Positive control and the extract significantly (p< 0.05) reduced wound size on days 1-5 and 7-9 respectively. Se2+ added extract significantly (p< 0.05) increased the enzymes’ activities on day 4 and 10 compared to negative control and day 4 only when compared to positive control. Remaining treatments significantly (p< 0.05) increased activity of catalase on day 4 and 10 and superoxide dismutase on day 4 only when compared to negative control. All treatments significantly (p< 0.05) decreased lipid peroxidation at day 4 and 10 post wounding. Thus, Se2+ added papaya extracts provide increased protection against oxidative damage during wound repair. Keywords: Papaya extract, wound healing, Se, Zn and antioxidant enzymes 2014 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf Nafiu, Bidemi Abdulrazaq and Rahman, Mohammad Tariqur (2014) Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition. In: 1st International Conference on Food Properties (iCFP2014), 24-26 January 2014, Kuala Lumpur, Malaysia. http://www.ieomrs.com/icfp/cfp.html |
| spellingShingle | Q Science (General) Nafiu, Bidemi Abdulrazaq Rahman, Mohammad Tariqur Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title | Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title_full | Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title_fullStr | Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title_full_unstemmed | Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title_short | Antioxidant activity of papaya extract during wound healing is enhanced by Se2+ addition |
| title_sort | antioxidant activity of papaya extract during wound healing is enhanced by se2+ addition |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/35982/ http://irep.iium.edu.my/35982/ http://irep.iium.edu.my/35982/1/Antioxidant_activity_of_papaya_extract.pdf |