The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study
This study aims to assess follicle preservation in mature female mice with the provision of Nigella Sativa oil against effects of cyclophosphamide which can cause ovarian follicular loss. Forty-eight ICR mice aged 18 weeks were divided into 3 groups: group I = control, group II = cyclophosphamide-al...
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| Format: | Article |
| Language: | English English |
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Pakistan Agricultural Scientists Forum (PAS FORUM)
2014
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| Online Access: | http://irep.iium.edu.my/35720/ http://irep.iium.edu.my/35720/1/JAPS_Suzanah.pdf http://irep.iium.edu.my/35720/4/35720_effect%20of%20Nigella%20Sativa_scopus.pdf |
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| author | Abdul Rahman, Suzanah Sha'ban, Munirah Kamarzaman, Saheera |
| author_facet | Abdul Rahman, Suzanah Sha'ban, Munirah Kamarzaman, Saheera |
| author_sort | Abdul Rahman, Suzanah |
| building | IIUM Repository |
| collection | Online Access |
| description | This study aims to assess follicle preservation in mature female mice with the provision of Nigella Sativa oil against effects of cyclophosphamide which can cause ovarian follicular loss. Forty-eight ICR mice aged 18 weeks were divided into 3 groups: group I = control, group II = cyclophosphamide-alone (50mg/kg) for 5, 10, 15 and 20 days; and group III = pre-treated with different doses of Nigella sativa oil (0.2ml, 0.5ml and 1.0ml/100g) for 5 days, all by intraperitoneal injection. The histology and the total number of ovarian follicles were studied. Results show that the number of primordial follicles following exposure to cyclophosphamide was significantly reduced (36.33 ± 5.86)as compared to the controls (86.67 ±32.52) at day 10 (p<0.05). There was also a significant reduction in the mean number of normal primary and secondary follicles (p<0.001), mean ovarian diameters (p<0.05) and an increased vacuolation with irregular distribution of granulosa cells. The numbers of normal primary and secondary follicles including ovarian diameters were significantly increased in the use of Nigella sativa as opposed to effects seen in controls and cyclophosphamide-alone groups at day 5. This study seems to suggest a prophylactic property of Nigella sativa in the reproductive system of female mice. |
| first_indexed | 2025-11-14T15:44:12Z |
| format | Article |
| id | iium-35720 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:44:12Z |
| publishDate | 2014 |
| publisher | Pakistan Agricultural Scientists Forum (PAS FORUM) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-357202017-09-19T04:20:14Z http://irep.iium.edu.my/35720/ The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study Abdul Rahman, Suzanah Sha'ban, Munirah Kamarzaman, Saheera QP Physiology R Medicine (General) RM300 Drugs and their action This study aims to assess follicle preservation in mature female mice with the provision of Nigella Sativa oil against effects of cyclophosphamide which can cause ovarian follicular loss. Forty-eight ICR mice aged 18 weeks were divided into 3 groups: group I = control, group II = cyclophosphamide-alone (50mg/kg) for 5, 10, 15 and 20 days; and group III = pre-treated with different doses of Nigella sativa oil (0.2ml, 0.5ml and 1.0ml/100g) for 5 days, all by intraperitoneal injection. The histology and the total number of ovarian follicles were studied. Results show that the number of primordial follicles following exposure to cyclophosphamide was significantly reduced (36.33 ± 5.86)as compared to the controls (86.67 ±32.52) at day 10 (p<0.05). There was also a significant reduction in the mean number of normal primary and secondary follicles (p<0.001), mean ovarian diameters (p<0.05) and an increased vacuolation with irregular distribution of granulosa cells. The numbers of normal primary and secondary follicles including ovarian diameters were significantly increased in the use of Nigella sativa as opposed to effects seen in controls and cyclophosphamide-alone groups at day 5. This study seems to suggest a prophylactic property of Nigella sativa in the reproductive system of female mice. Pakistan Agricultural Scientists Forum (PAS FORUM) 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35720/1/JAPS_Suzanah.pdf application/pdf en http://irep.iium.edu.my/35720/4/35720_effect%20of%20Nigella%20Sativa_scopus.pdf Abdul Rahman, Suzanah and Sha'ban, Munirah and Kamarzaman, Saheera (2014) The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study. The Journal of Animal and Plant Sciences, 24 (1). pp. 81-88. ISSN 1018-7081 http://www.thejaps.org.pk/Volume/2014/24-1/default.asp |
| spellingShingle | QP Physiology R Medicine (General) RM300 Drugs and their action Abdul Rahman, Suzanah Sha'ban, Munirah Kamarzaman, Saheera The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title | The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title_full | The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title_fullStr | The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title_full_unstemmed | The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title_short | The prophylactic effect of Nigella sativa against Cyclophosphamide in the ovarian follicles of matured adult mice: A preliminary study |
| title_sort | prophylactic effect of nigella sativa against cyclophosphamide in the ovarian follicles of matured adult mice: a preliminary study |
| topic | QP Physiology R Medicine (General) RM300 Drugs and their action |
| url | http://irep.iium.edu.my/35720/ http://irep.iium.edu.my/35720/ http://irep.iium.edu.my/35720/1/JAPS_Suzanah.pdf http://irep.iium.edu.my/35720/4/35720_effect%20of%20Nigella%20Sativa_scopus.pdf |